Thrombosis

Thrombosis resulting from various pathologies is the underlying cause of the majority of ischemic strokes. Hemostasis is the complex and highly regulated system that helps to maintain the integrity of blood and the vasculature. Maintenance of blood flow depends upon an intact and fully functional vascular endothelium. Thrombosis is one of the pathological consequences when the hemostatic system is activated within the circulation itself often as a result of disruption or derangements in the vascular endothelium. Although the concept dates back at least 250. years to the time of the Scottish surgeon John Hunter, the current understanding of how thrombotic events happen increasingly links inflammatory mechanisms with thrombosis.