Thrombomodulin: A new marker for placental abruption

Urania Magriples, Daniel W. Chan, Debra Bruzek, Joshua A. Copel, Chaur Dong Hsu

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Thrombomodulin (TM), a marker of endothelial cell damage, has been localized to the placental syncytiotrophoblast. A prospective cohort study of twenty-five pregnant women who were admitted with a clinical diagnosis of placental abruption was undertaken. Abruption was confirmed after delivery in eight cases (Group 1). Group 2 consisted of seventeen patients with no clinical or pathologic evidence of placental abruption after delivery. This was significantly elevated in Group 1 (71.59 ± 5.35 vs. 48.29 ± 3.53 ng/ml, p = 0.001). The sensitivity and specificity of TM ≥ 60 ng/ml as a marker for abruption was 87.5 and 76.5%, respectively. In comparison, the sensitivity of an abnormal coagulation profile, maternal Kleihauer-Betke and ultrasound in patients with abruption was 0, 16.7 and 28.6%, respectively. TM is a highly sensitive and specific marker for acute placental abruption.

Original languageEnglish (US)
Pages (from-to)32-34
Number of pages3
JournalThrombosis and Haemostasis
Issue number1
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Hematology


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