Thrombolytic therapy of acute ischemic stroke during pregnancy

A. Murugappan; W. M. Coplin; A. N. Al-Sadat; K. J. McAllen; L. H. Schwamm; L. R. Wechsler; C. S. Kidwell; J. L. Saver; S. Starkman; Y. P. Gobin; G. Duckwiler; M. Krueger; G. Rordorf; J. P. Broderick; G. E. Tietjen; S. R. Levine

doi:10.1212/01.wnl.0000201272.90216.15

Thrombolytic therapy of acute ischemic stroke during pregnancy

A. Murugappan, W. M. Coplin, A. N. Al-Sadat, K. J. McAllen, L. H. Schwamm, L. R. Wechsler, C. S. Kidwell, J. L. Saver, S. Starkman, Y. P. Gobin, G. Duckwiler, M. Krueger, G. Rordorf, J. P. Broderick, G. E. Tietjen, S. R. Levine

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

The authors report eight pregnant women with acute ischemic stroke treated with thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven women recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, two fetuses were miscarried, and two babies were delivered healthy. Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed.

Original language	English (US)
Pages (from-to)	768-770
Number of pages	3
Journal	Neurology
Volume	66
Issue number	5
DOIs	https://doi.org/10.1212/01.wnl.0000201272.90216.15
State	Published - Mar 2006
Externally published	Yes

ASJC Scopus subject areas

Clinical Neurology

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Murugappan, A., Coplin, W. M., Al-Sadat, A. N., McAllen, K. J., Schwamm, L. H., Wechsler, L. R., Kidwell, C. S., Saver, J. L., Starkman, S., Gobin, Y. P., Duckwiler, G., Krueger, M., Rordorf, G., Broderick, J. P., Tietjen, G. E., & Levine, S. R. (2006). Thrombolytic therapy of acute ischemic stroke during pregnancy. Neurology, 66(5), 768-770. https://doi.org/10.1212/01.wnl.0000201272.90216.15

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title = "Thrombolytic therapy of acute ischemic stroke during pregnancy",

abstract = "The authors report eight pregnant women with acute ischemic stroke treated with thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven women recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, two fetuses were miscarried, and two babies were delivered healthy. Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed.",

author = "A. Murugappan and Coplin, {W. M.} and Al-Sadat, {A. N.} and McAllen, {K. J.} and Schwamm, {L. H.} and Wechsler, {L. R.} and Kidwell, {C. S.} and Saver, {J. L.} and S. Starkman and Gobin, {Y. P.} and G. Duckwiler and M. Krueger and G. Rordorf and Broderick, {J. P.} and Tietjen, {G. E.} and Levine, {S. R.}",

note = "Funding Information: Supported in part by NIH grants NS 38905 (W.M.C.) and 43992 (S.R.L.). ",

year = "2006",

month = mar,

doi = "10.1212/01.wnl.0000201272.90216.15",

language = "English (US)",

volume = "66",

pages = "768--770",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

TY - JOUR

T1 - Thrombolytic therapy of acute ischemic stroke during pregnancy

AU - Murugappan, A.

AU - Coplin, W. M.

AU - Al-Sadat, A. N.

AU - McAllen, K. J.

AU - Schwamm, L. H.

AU - Wechsler, L. R.

AU - Kidwell, C. S.

AU - Saver, J. L.

AU - Starkman, S.

AU - Gobin, Y. P.

AU - Duckwiler, G.

AU - Krueger, M.

AU - Rordorf, G.

AU - Broderick, J. P.

AU - Tietjen, G. E.

AU - Levine, S. R.

N1 - Funding Information: Supported in part by NIH grants NS 38905 (W.M.C.) and 43992 (S.R.L.).

PY - 2006/3

Y1 - 2006/3

N2 - The authors report eight pregnant women with acute ischemic stroke treated with thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven women recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, two fetuses were miscarried, and two babies were delivered healthy. Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed.

AB - The authors report eight pregnant women with acute ischemic stroke treated with thrombolysis (rt-PA [recombinant human tissue plasminogen activator] or urokinase). Seven women recovered. Two extracranial and two asymptomatic intracranial hemorrhages complicated treatment; one woman died of arterial dissection complicating angiography. Three patients had therapeutic abortions, two fetuses were miscarried, and two babies were delivered healthy. Although pregnant women may be treated safely with thrombolytics, risks and benefits to mother and fetus must be carefully weighed.

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DO - 10.1212/01.wnl.0000201272.90216.15

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AN - SCOPUS:33645882952

SN - 0028-3878

VL - 66

SP - 768

EP - 770

JO - Neurology

JF - Neurology

IS - 5

ER -

Thrombolytic therapy of acute ischemic stroke during pregnancy

Abstract

ASJC Scopus subject areas

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