Thrombogenicity of cardiovascular devices: mutual and relative effect of biomaterial and shear stress

S. Bozzi, F. Vercellino, Filippo Consolo, Yana Roka Moiia, Tatiana Mercarini, Marvin Slepian, A. Redaelli

Research output: Contribution to journalConference articlepeer-review


Supra-physiologic levels of shear stress and blood contact with artificial material are considered the main causes of the thrombogenicity of cardiovascular devices, such as prosthetic heart valves and ventricular assist devices. To investigate the mutual and relative role of these factors in platelet activation a set of experiments was performed consisting in the evaluation of platelet activation in samples of isolated platelets exposed to different levels of shear stress and different materials. The results showed that 1) platelet activation by mechanical stimuli exhibits a dose-time-response, which depends on the material in contact with the platelets, 2) biomaterials have a different thrombogenic potential, being polyethylene the least thrombogenic among the ones investigated and 3) the contact with an artificial material and the mechanical stimulation have approximately the same effect on platelet activation.

Original languageEnglish (US)
Pages (from-to)572-575
Number of pages4
JournalConvegno Nazionale di Bioingegneria
StatePublished - 2020
Externally publishedYes
Event7th National Congress of Bioengineering, GNB 2020 - Trieste, Italy
Duration: Jun 9 2020Jun 11 2020


  • biomaterial
  • Cardiovascular devices
  • platelet activation
  • shear stress

ASJC Scopus subject areas

  • Biomedical Engineering


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