TY - JOUR
T1 - Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses
AU - Wong-Staal, Flossie
AU - Dalla-Favera, Riccardo
AU - Franchini, Genoveffa
AU - Gelmann, Edward P.
AU - Gallo, Robert C.
PY - 1981
Y1 - 1981
N2 - Southern blot hybridization was used to identify human and other vertebrate DNA sequences that were homologous to cloned DNA fragments containing the oncogenic nucleic acid sequences of three different type C mammalian retroviruses (simian sarcoma virus, the Snyder-Theilen strain of feline sarcoma virus, and the Harvey strain of murine sarcoma virus). Each one gene counterpart has a single genetic locus, which probably contains non-one intervening sequences. The human DNA sequences may represent genes important to cell growth or cell differentiation, or both. Their identification and isolation may allow elucidation of their role in these processes and in neoplasias.
AB - Southern blot hybridization was used to identify human and other vertebrate DNA sequences that were homologous to cloned DNA fragments containing the oncogenic nucleic acid sequences of three different type C mammalian retroviruses (simian sarcoma virus, the Snyder-Theilen strain of feline sarcoma virus, and the Harvey strain of murine sarcoma virus). Each one gene counterpart has a single genetic locus, which probably contains non-one intervening sequences. The human DNA sequences may represent genes important to cell growth or cell differentiation, or both. Their identification and isolation may allow elucidation of their role in these processes and in neoplasias.
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U2 - 10.1126/science.6264598
DO - 10.1126/science.6264598
M3 - Article
C2 - 6264598
AN - SCOPUS:0019830453
VL - 213
SP - 226
EP - 228
JO - Science
JF - Science
SN - 0036-8075
IS - 4504
ER -