Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses

Flossie Wong-Staal, Riccardo Dalla-Favera, Genoveffa Franchini, Edward P. Gelmann, Robert C. Gallo

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Southern blot hybridization was used to identify human and other vertebrate DNA sequences that were homologous to cloned DNA fragments containing the oncogenic nucleic acid sequences of three different type C mammalian retroviruses (simian sarcoma virus, the Snyder-Theilen strain of feline sarcoma virus, and the Harvey strain of murine sarcoma virus). Each one gene counterpart has a single genetic locus, which probably contains non-one intervening sequences. The human DNA sequences may represent genes important to cell growth or cell differentiation, or both. Their identification and isolation may allow elucidation of their role in these processes and in neoplasias.

Original languageEnglish (US)
Pages (from-to)226-228
Number of pages3
JournalScience
Volume213
Issue number4504
DOIs
StatePublished - 1981
Externally publishedYes

ASJC Scopus subject areas

  • General

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