Three-dimensional structure of the complex between a T cell receptor β chain and the superantigen staphylococcal enterotoxin B

Li Hongmin, Andrea Llera, Daisuke Tsuchiya, Lukas Leder, Xavier Ysern, Patrick M. Schlievert, Klaus Karjalainen, Roy A. Mariuzza

Research output: Contribution to journalArticlepeer-review

155 Scopus citations

Abstract

Superantigens (SAGs) are a class of immunostimulatory proteins of bacterial or viral origin that activate T cells by binding to the Vβ domain of the T cell antigen receptor (TCR). The three-dimensional structure of the complex between a TCR β chain (mouse Vβ8.2) and the SAG staphylococcal enterotoxin B (SEB) at 2.4 A resolution reveals why SEB recognizes only certain Vβ families, as well as why only certain SAGs bind mouse Vβ8.2. Models of the TCR-SEB-peptide/MHC class II complex indicate that Vα interacts with the MHC β chain in the TCR-SAG-MHC complex. The extent of the interaction is variable and is largely determined by the geometry of Vα/Vβ domain association. This variability can account for the preferential expression of certain Vα regions among T cells reactive with SEB.

Original languageEnglish (US)
Pages (from-to)807-816
Number of pages10
JournalImmunity
Volume9
Issue number6
DOIs
StatePublished - Dec 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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