Abstract
Superantigens (SAGs) are a class of immunostimulatory proteins of bacterial or viral origin that activate T cells by binding to the Vβ domain of the T cell antigen receptor (TCR). The three-dimensional structure of the complex between a TCR β chain (mouse Vβ8.2) and the SAG staphylococcal enterotoxin B (SEB) at 2.4 A resolution reveals why SEB recognizes only certain Vβ families, as well as why only certain SAGs bind mouse Vβ8.2. Models of the TCR-SEB-peptide/MHC class II complex indicate that Vα interacts with the MHC β chain in the TCR-SAG-MHC complex. The extent of the interaction is variable and is largely determined by the geometry of Vα/Vβ domain association. This variability can account for the preferential expression of certain Vα regions among T cells reactive with SEB.
Original language | English (US) |
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Pages (from-to) | 807-816 |
Number of pages | 10 |
Journal | Immunity |
Volume | 9 |
Issue number | 6 |
DOIs | |
State | Published - Dec 1998 |
Externally published | Yes |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases