Abstract
Aminomethylated Beaucage's reagent 1 was found to be more potent than 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage's reagent) in causing DNA cleavage. The current study demonstrated the importance of the amino functionality in enhancing DNA-cleaving activities, and such findings may facilitate development of novel sulfur-containing DNA-cleaving molecules in cancer therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1293-1295 |
| Number of pages | 3 |
| Journal | Organic and Biomolecular Chemistry |
| Volume | 8 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2010 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry