Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent

Jiahui Zheng, Xiaoqian Liu, Qing Yuan, Yoon Joo Shin, Daekyu Sun, Yixin Lu

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Aminomethylated Beaucage's reagent 1 was found to be more potent than 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage's reagent) in causing DNA cleavage. The current study demonstrated the importance of the amino functionality in enhancing DNA-cleaving activities, and such findings may facilitate development of novel sulfur-containing DNA-cleaving molecules in cancer therapy.

Original languageEnglish (US)
Pages (from-to)1293-1295
Number of pages3
JournalOrganic and Biomolecular Chemistry
Issue number6
StatePublished - 2010

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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