Aminomethylated Beaucage's reagent 1 was found to be more potent than 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage's reagent) in causing DNA cleavage. The current study demonstrated the importance of the amino functionality in enhancing DNA-cleaving activities, and such findings may facilitate development of novel sulfur-containing DNA-cleaving molecules in cancer therapy.
|Original language||English (US)|
|Number of pages||3|
|Journal||Organic and Biomolecular Chemistry|
|State||Published - 2010|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry