Abstract
The objective of this study was to create a wound healing model based on longitudinal thermal images of wounds to assess the pro-angiogenic properties of Eu(OH)3 nanorods using an in vivo animal model. Eu(OH)3 nanorods are bioactive nanoparticles and induce angiogenesis which results in relatively faster skin wound healing in diabetics. We tracked wound area of full thickness cutaneous wounds for 18 days using digital photographs and wound temperature using infrared imaging as a surrogate indictor for inflammation. Cutaneous wound area decreased faster for mice treated with Eu(OH) 3 than those treated with control vehicle dressing [62% (Europium) Vs 43% (Control) wound area reduction at Day 18]. This study provides a novel methodology to assess wound healing for in-vivo models using thermography.
Original language | English (US) |
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Pages (from-to) | 228-232 |
Number of pages | 5 |
Journal | Simulation Series |
Volume | 46 |
Issue number | 10 |
State | Published - 2014 |
Event | Summer Computer Simulation Conference, SCSC 2014, Part of the 2014 Summer Simulation Multiconference, SummerSim 2014 - Monterey, United States Duration: Jul 6 2014 → Jul 10 2014 |
Keywords
- Angiogenesis
- Diabetic Wound Healing
- Inflammation
- Nano-technology
- Thermography
ASJC Scopus subject areas
- Computer Networks and Communications