Thermodynamics of Glucagon Aggregation

Robert E. Johnson, Victor J. Hruby, John A. Rupley

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Heats of dilution of concentrated glucagon solutions have been measured calorimetrically at 10 and 25 °C in 0.2 M potassium phosphate buffer of pH 10.6. Analysis of the data in terms of a monomer-trimer equilibrium gives the following thermodynamic parameters for the association reaction at 25 °C: ΔG°=-7.34 kcal/mol of trimer, ΔH°=-31.2 kcal/mol, ΔS°=-80 cal/(K mol), ΔCp=-430 cal/(K mol). The sensitivity of heat of dilution data to the association constant and stoichiometry of the reaction is discussed.

Original languageEnglish (US)
Pages (from-to)1176-1179
Number of pages4
Issue number7
StatePublished - 1979

ASJC Scopus subject areas

  • Biochemistry


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