Therapeutic Strategies to Limit Lung Endothelial Cell Permeability

Rachel K. Wolfson, Gabriel Lang, Jeff Jacobson, Joe G.N. Garcia

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations
Original languageEnglish (US)
Title of host publicationThe Pulmonary Endothelium
Subtitle of host publicationFunction in health and disease
PublisherJohn Wiley & Sons, Ltd
Number of pages18
ISBN (Print)9780470723616
StatePublished - Sep 11 2009


  • Acute (inflammatory) lung injury (ALI)
  • Intracellular signaling pathways and EC edemagenic agents
  • Methylnaltrexone (MNTX) - peripherally restricted mu opioid receptor (mOP-R) antagonist
  • Oxidized phospholipids
  • Receptor-mediated barrier protection - role of RAC GTPase
  • S1P
  • Simvastatin-mediated thrombin inhibition
  • Sphingolipid from sphingosine phosphorylation
  • Therapeutic strategies limiting lung endothelial cell permeability
  • Vascular endothelium - primary cellular target in physiologic derangement

ASJC Scopus subject areas

  • General Medicine

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