Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice

Hua Zhu; Yi Xiong; Yunqiu Xia; Rong Zhang; Daiyin Tian; Ting Wang; Jihong Dai; Lijia Wang; Hongbing Yao; Hong Jiang; Ke Yang; Enmei Liu; Yujun Shi; Zhou Fu; Li Gao; Lin Zou

doi:10.1038/srep39889

Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice

Hua Zhu
, Yi Xiong
, Yunqiu Xia
, Rong Zhang
, Daiyin Tian
, Ting Wang
, Jihong Dai
, Lijia Wang
, Hongbing Yao
, Hong Jiang
, Ke Yang
, Enmei Liu
, Yujun Shi
, Zhou Fu
, Li Gao
, Lin Zou

Medicine

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration of human umbilical cord-mesenchymal stem cells (UC-MSCs) significantly improved survival and attenuated the lung inflammation in lipopolysaccharide (LPS)-induced ALI mice. We also used the proteins-chip and bioinformatics to analyze interactions between UC-MSCs treatment and immune-response alternations of ALI mice. Then we demonstrated that UC-MSCs could inhibit the inflammatory response of mouse macrophage in ALI mice, as well as enhance its IL-10 expression. We provide data to support the concept that the therapeutic capacity of UC-MSCs for ALI was primarily through paracrine secretion, particularly of prostaglandin-E2 (PGE2). Furthermore, we showed that UC-MSCs might secrete a panel of factors including GM-CSF, IL-6 and IL-13 to ameliorate ALI. Our study suggested that UC-MSCs could protect LPS-induced ALI model by immune regulation and paracrine factors, indicating that UC-MSCs should be a promising strategy for ALI/ARDS.

Original language	English (US)
Article number	39889
Journal	Scientific reports
Volume	7
DOIs	https://doi.org/10.1038/srep39889
State	Published - Jan 4 2017

ASJC Scopus subject areas

General

Access to Document

10.1038/srep39889

Cite this

@article{0d925803b40f4064a9f94579fe93c7d5,

title = "Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice",

abstract = "The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration of human umbilical cord-mesenchymal stem cells (UC-MSCs) significantly improved survival and attenuated the lung inflammation in lipopolysaccharide (LPS)-induced ALI mice. We also used the proteins-chip and bioinformatics to analyze interactions between UC-MSCs treatment and immune-response alternations of ALI mice. Then we demonstrated that UC-MSCs could inhibit the inflammatory response of mouse macrophage in ALI mice, as well as enhance its IL-10 expression. We provide data to support the concept that the therapeutic capacity of UC-MSCs for ALI was primarily through paracrine secretion, particularly of prostaglandin-E2 (PGE2). Furthermore, we showed that UC-MSCs might secrete a panel of factors including GM-CSF, IL-6 and IL-13 to ameliorate ALI. Our study suggested that UC-MSCs could protect LPS-induced ALI model by immune regulation and paracrine factors, indicating that UC-MSCs should be a promising strategy for ALI/ARDS.",

author = "Hua Zhu and Yi Xiong and Yunqiu Xia and Rong Zhang and Daiyin Tian and Ting Wang and Jihong Dai and Lijia Wang and Hongbing Yao and Hong Jiang and Ke Yang and Enmei Liu and Yujun Shi and Zhou Fu and Li Gao and Lin Zou",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2017.",

year = "2017",

month = jan,

day = "4",

doi = "10.1038/srep39889",

language = "English (US)",

volume = "7",

journal = "Scientific reports",

issn = "2045-2322",

publisher = "Nature Research",

}

TY - JOUR

T1 - Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice

AU - Zhu, Hua

AU - Xiong, Yi

AU - Xia, Yunqiu

AU - Zhang, Rong

AU - Tian, Daiyin

AU - Wang, Ting

AU - Dai, Jihong

AU - Wang, Lijia

AU - Yao, Hongbing

AU - Jiang, Hong

AU - Yang, Ke

AU - Liu, Enmei

AU - Shi, Yujun

AU - Fu, Zhou

AU - Gao, Li

AU - Zou, Lin

PY - 2017/1/4

Y1 - 2017/1/4

N2 - The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration of human umbilical cord-mesenchymal stem cells (UC-MSCs) significantly improved survival and attenuated the lung inflammation in lipopolysaccharide (LPS)-induced ALI mice. We also used the proteins-chip and bioinformatics to analyze interactions between UC-MSCs treatment and immune-response alternations of ALI mice. Then we demonstrated that UC-MSCs could inhibit the inflammatory response of mouse macrophage in ALI mice, as well as enhance its IL-10 expression. We provide data to support the concept that the therapeutic capacity of UC-MSCs for ALI was primarily through paracrine secretion, particularly of prostaglandin-E2 (PGE2). Furthermore, we showed that UC-MSCs might secrete a panel of factors including GM-CSF, IL-6 and IL-13 to ameliorate ALI. Our study suggested that UC-MSCs could protect LPS-induced ALI model by immune regulation and paracrine factors, indicating that UC-MSCs should be a promising strategy for ALI/ARDS.

AB - The incidence and mortality of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are still very high, but stem cells show some promise for its treatment. Here we found that intratracheal administration of human umbilical cord-mesenchymal stem cells (UC-MSCs) significantly improved survival and attenuated the lung inflammation in lipopolysaccharide (LPS)-induced ALI mice. We also used the proteins-chip and bioinformatics to analyze interactions between UC-MSCs treatment and immune-response alternations of ALI mice. Then we demonstrated that UC-MSCs could inhibit the inflammatory response of mouse macrophage in ALI mice, as well as enhance its IL-10 expression. We provide data to support the concept that the therapeutic capacity of UC-MSCs for ALI was primarily through paracrine secretion, particularly of prostaglandin-E2 (PGE2). Furthermore, we showed that UC-MSCs might secrete a panel of factors including GM-CSF, IL-6 and IL-13 to ameliorate ALI. Our study suggested that UC-MSCs could protect LPS-induced ALI model by immune regulation and paracrine factors, indicating that UC-MSCs should be a promising strategy for ALI/ARDS.

UR - https://www.scopus.com/pages/publications/85008323993

UR - https://www.scopus.com/pages/publications/85008323993#tab=citedBy

U2 - 10.1038/srep39889

DO - 10.1038/srep39889

M3 - Article

C2 - 28051154

AN - SCOPUS:85008323993

SN - 2045-2322

VL - 7

JO - Scientific reports

JF - Scientific reports

M1 - 39889

ER -

Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this