Therapeutic Cancer Vaccines—Antigen Discovery and Adjuvant Delivery Platforms

Neftali Ortega Alarcon, Maddy Jaramillo, Heidi M. Mansour, Bo Sun

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


For decades, vaccines have played a significant role in protecting public and personal health against infectious diseases and proved their great potential in battling cancers as well. This review focused on the current progress of therapeutic subunit vaccines for cancer immunotherapy. Antigens and adjuvants are key components of vaccine formulations. We summarized several classes of tumor antigens and bioinformatic approaches of identification of tumor neoantigens. Pattern recognition receptor (PRR)-targeting adjuvants and their targeted delivery platforms have been extensively discussed. In addition, we emphasized the interplay between multiple adjuvants and their combined delivery for cancer immunotherapy.

Original languageEnglish (US)
Article number1448
Issue number7
StatePublished - Jul 2022


  • adjuvants
  • combination therapies
  • delivery systems
  • therapeutic vaccine
  • tumor antigens

ASJC Scopus subject areas

  • Pharmaceutical Science


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