Therapeutic applications of microbubbles

Evan C Unger; Terry Onichi Matsunaga; Thomas McCreery; Patricia Schumann; Robert Sweitzer; Rachel Quigley

doi:10.1016/S0720-048X(01)00455-7

Therapeutic applications of microbubbles

Evan C Unger, Terry Onichi Matsunaga, Thomas McCreery, Patricia Schumann, Robert Sweitzer, Rachel Quigley

Research output: Contribution to journal › Article › peer-review

285 Scopus citations

Abstract

Microbubbles, currently used as contrast agents have potential therapeutic applications. Microbubbles, upon insonation of sufficiently intense ultrasound will cavitate. Cavitation with microbubbles can be used to dissolve blood clots or deliver drugs. Targeting ligands and drugs can be incorporated into microbubbles to make highly specific diagnostic and therapeutic agents for activation with ultrasound. In this paper I will review some of these potential applications and experimental results using such agents for thrombolysis, drug and gene delivery.

Original language	English (US)
Pages (from-to)	160-168
Number of pages	9
Journal	European Journal of Radiology
Volume	42
Issue number	2
DOIs	https://doi.org/10.1016/S0720-048X(01)00455-7
State	Published - 2002
Externally published	Yes

Keywords

Drug delivery
Gene delivery
Microbubbles
Therapy
Thrombolysis
Ultrasound

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1016/S0720-048X(01)00455-7

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AU - Matsunaga, Terry Onichi

AU - McCreery, Thomas

AU - Schumann, Patricia

AU - Sweitzer, Robert

AU - Quigley, Rachel

PY - 2002

Y1 - 2002

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AB - Microbubbles, currently used as contrast agents have potential therapeutic applications. Microbubbles, upon insonation of sufficiently intense ultrasound will cavitate. Cavitation with microbubbles can be used to dissolve blood clots or deliver drugs. Targeting ligands and drugs can be incorporated into microbubbles to make highly specific diagnostic and therapeutic agents for activation with ultrasound. In this paper I will review some of these potential applications and experimental results using such agents for thrombolysis, drug and gene delivery.

KW - Drug delivery

KW - Gene delivery

KW - Microbubbles

KW - Therapy

KW - Thrombolysis

KW - Ultrasound

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JO - European Journal of Radiology

JF - European Journal of Radiology

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Therapeutic applications of microbubbles

Abstract

Keywords

ASJC Scopus subject areas

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