Theoretical study of structural adaptation in microvascular networks: effect of metabolic response on distribution of blood flow between long and short pathways

Gabriel Gruionu; Timothy W. Secomb; Axel R. Pries

Theoretical study of structural adaptation in microvascular networks: effect of metabolic response on distribution of blood flow between long and short pathways

Gabriel Gruionu, Timothy W. Secomb, Axel R. Pries

Research output: Contribution to journal › Conference article › peer-review

Abstract

The goal of the present study was to investigate how the process of vascular adaptation can ensure that the flow is well distributed among flow pathways through the network, even though the pressure gradient is higher in shorter pathways. A previously developed theoretical model was used to simulate the effect of the metabolic response on flow distribution in a simple hypothetical network with two long flow pathways and one shorter pathway between the inflow and the outflow. The metabolic response represents the tendency of a slowly flowing, poorly oxygenated segment to increase its diameter.

Original language	English (US)
Pages (from-to)	S-70-S-71
Journal	Annals of Biomedical Engineering
Volume	28
Issue number	SUPPL. 1
State	Published - 2000
Event	2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA Duration: Oct 12 2000 → Oct 14 2000

ASJC Scopus subject areas

Biomedical Engineering

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Theoretical study of structural adaptation in microvascular networks: effect of metabolic response on distribution of blood flow between long and short pathways. / Gruionu, Gabriel; Secomb, Timothy W.; Pries, Axel R.
In: Annals of Biomedical Engineering, Vol. 28, No. SUPPL. 1, 2000, p. S-70-S-71.

Research output: Contribution to journal › Conference article › peer-review

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AB - The goal of the present study was to investigate how the process of vascular adaptation can ensure that the flow is well distributed among flow pathways through the network, even though the pressure gradient is higher in shorter pathways. A previously developed theoretical model was used to simulate the effect of the metabolic response on flow distribution in a simple hypothetical network with two long flow pathways and one shorter pathway between the inflow and the outflow. The metabolic response represents the tendency of a slowly flowing, poorly oxygenated segment to increase its diameter.

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ER -

Theoretical study of structural adaptation in microvascular networks: effect of metabolic response on distribution of blood flow between long and short pathways

Abstract

ASJC Scopus subject areas

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