TY - CHAP
T1 - The Women’s Health Initiative
T2 - Lessons for Preventive Nutrition
AU - Thomson, Cynthia A.
AU - L. Neuhouser, Marian
AU - Beresford, Shirley A.A.
N1 - Publisher Copyright:
© Springer International Publishing Switzerland 2015.
PY - 2015
Y1 - 2015
N2 - Towards the end of the 1980s, considerable evidence was accumulating from observational studies and some short-term trials with non-disease endpoints that identified factors that might benefit women in their postmenopausal years. The balance of randomized trials prior to that point had been focused on men and men’s health. The confluence of scientific discovery and political will led to the design and ultimate funding of what was to be known as the Women’s Health Initiative (WHI). Two main factors in this category were postmenopausal hormone replacement therapy (hormone therapy), suggested to prevent cardiovascular disease (CVD), the number one cause of death among women, and total dietary fat reduction for purposes of reducing risk for breast and colorectal cancers, also major causes of death and disability among women. These became the two, overlapping, main trials that were the core of WHI.
AB - Towards the end of the 1980s, considerable evidence was accumulating from observational studies and some short-term trials with non-disease endpoints that identified factors that might benefit women in their postmenopausal years. The balance of randomized trials prior to that point had been focused on men and men’s health. The confluence of scientific discovery and political will led to the design and ultimate funding of what was to be known as the Women’s Health Initiative (WHI). Two main factors in this category were postmenopausal hormone replacement therapy (hormone therapy), suggested to prevent cardiovascular disease (CVD), the number one cause of death among women, and total dietary fat reduction for purposes of reducing risk for breast and colorectal cancers, also major causes of death and disability among women. These became the two, overlapping, main trials that were the core of WHI.
KW - Cancer
KW - Cardiovascular disease
KW - Clinical trial
KW - Diet
KW - Dietary adherence
KW - Postmenopausal women
UR - http://www.scopus.com/inward/record.url?scp=85213042600&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85213042600&partnerID=8YFLogxK
U2 - 10.1007/978-3-319-22431-2_19
DO - 10.1007/978-3-319-22431-2_19
M3 - Chapter
AN - SCOPUS:85213042600
T3 - Nutrition and Health (United Kingdom)
SP - 335
EP - 369
BT - Nutrition and Health (United Kingdom)
PB - Palgrave Macmillan
ER -