The use of focused ultrasound for the treatment of cutaneous allodynia associated with chronic migraine

Ian Walling; Drishti Panse; Lucy Gee; Teresa Maietta; Brian Kaszuba; Vignessh Kumar; Sara Gannon; Abigail Hellman; Paul Neubauer; Lance Frith; Emery Williams; Goutam Ghoshal; Damian S. Shin; Clif Burdette; Jian Qian; Julie G. Pilitsis

doi:10.1016/j.brainres.2018.08.004

The use of focused ultrasound for the treatment of cutaneous allodynia associated with chronic migraine

Ian Walling
, Drishti Panse
, Lucy Gee
, Teresa Maietta
, Brian Kaszuba
, Vignessh Kumar
, Sara Gannon
, Abigail Hellman
, Paul Neubauer
, Lance Frith
, Emery Williams
, Goutam Ghoshal
, Damian S. Shin
, Clif Burdette
, Jian Qian
, Julie G. Pilitsis

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Chronic migraines (CM) are the third most common disease and are refractory to medical treatment in 15% of patients. Currently, temporary relief is achieved with steroid blocks or pulsed radiofrequency ablation, which have short-term benefits. Our project aims to develop a non-invasive treatment for medically refractory chronic migraine, which does not require a permanent implant. This project investigates the safety and effectiveness of pulsed focused ultrasound (FUS) in a validated rodent headache model of cutaneous allodynia associated with chronic migraine (CM) as compared to sumatriptan and ablative lesioning. We demonstrate a significant reduction in mechanical thresholds as measured through Von Frey filaments in CM in the forepaw and periorbital region (p < 0.001). Sumatriptan and pulsed FUS both significantly improve thresholds at day 3 after treatment in the periorbital region. Ablative lesioning has no effect. This study provides initial evidence that FUS may provide an important therapeutic option for patients suffering from CM.

Original language	English (US)
Pages (from-to)	135-141
Number of pages	7
Journal	Brain Research
Volume	1699
DOIs	https://doi.org/10.1016/j.brainres.2018.08.004
State	Published - Nov 15 2018
Externally published	Yes

Keywords

Chronic migraine
Focused ultrasound
High intensity focused ultrasound
Mechanical threshold
Occipital nerve
Von Frey

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/j.brainres.2018.08.004

Cite this

Walling, I., Panse, D., Gee, L., Maietta, T., Kaszuba, B., Kumar, V., Gannon, S., Hellman, A., Neubauer, P., Frith, L., Williams, E., Ghoshal, G., Shin, D. S., Burdette, C., Qian, J., & Pilitsis, J. G. (2018). The use of focused ultrasound for the treatment of cutaneous allodynia associated with chronic migraine. Brain Research, 1699, 135-141. https://doi.org/10.1016/j.brainres.2018.08.004

Walling, I, Panse, D, Gee, L, Maietta, T, Kaszuba, B, Kumar, V, Gannon, S, Hellman, A, Neubauer, P, Frith, L, Williams, E, Ghoshal, G, Shin, DS, Burdette, C, Qian, J & Pilitsis, JG 2018, 'The use of focused ultrasound for the treatment of cutaneous allodynia associated with chronic migraine', Brain Research, vol. 1699, pp. 135-141. https://doi.org/10.1016/j.brainres.2018.08.004

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title = "The use of focused ultrasound for the treatment of cutaneous allodynia associated with chronic migraine",

abstract = "Chronic migraines (CM) are the third most common disease and are refractory to medical treatment in 15\% of patients. Currently, temporary relief is achieved with steroid blocks or pulsed radiofrequency ablation, which have short-term benefits. Our project aims to develop a non-invasive treatment for medically refractory chronic migraine, which does not require a permanent implant. This project investigates the safety and effectiveness of pulsed focused ultrasound (FUS) in a validated rodent headache model of cutaneous allodynia associated with chronic migraine (CM) as compared to sumatriptan and ablative lesioning. We demonstrate a significant reduction in mechanical thresholds as measured through Von Frey filaments in CM in the forepaw and periorbital region (p < 0.001). Sumatriptan and pulsed FUS both significantly improve thresholds at day 3 after treatment in the periorbital region. Ablative lesioning has no effect. This study provides initial evidence that FUS may provide an important therapeutic option for patients suffering from CM.",

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author = "Ian Walling and Drishti Panse and Lucy Gee and Teresa Maietta and Brian Kaszuba and Vignessh Kumar and Sara Gannon and Abigail Hellman and Paul Neubauer and Lance Frith and Emery Williams and Goutam Ghoshal and Shin, \{Damian S.\} and Clif Burdette and Jian Qian and Pilitsis, \{Julie G.\}",

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AU - Gannon, Sara

AU - Hellman, Abigail

AU - Neubauer, Paul

AU - Frith, Lance

AU - Williams, Emery

AU - Ghoshal, Goutam

AU - Shin, Damian S.

AU - Burdette, Clif

AU - Qian, Jian

AU - Pilitsis, Julie G.

PY - 2018/11/15

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N2 - Chronic migraines (CM) are the third most common disease and are refractory to medical treatment in 15% of patients. Currently, temporary relief is achieved with steroid blocks or pulsed radiofrequency ablation, which have short-term benefits. Our project aims to develop a non-invasive treatment for medically refractory chronic migraine, which does not require a permanent implant. This project investigates the safety and effectiveness of pulsed focused ultrasound (FUS) in a validated rodent headache model of cutaneous allodynia associated with chronic migraine (CM) as compared to sumatriptan and ablative lesioning. We demonstrate a significant reduction in mechanical thresholds as measured through Von Frey filaments in CM in the forepaw and periorbital region (p < 0.001). Sumatriptan and pulsed FUS both significantly improve thresholds at day 3 after treatment in the periorbital region. Ablative lesioning has no effect. This study provides initial evidence that FUS may provide an important therapeutic option for patients suffering from CM.

AB - Chronic migraines (CM) are the third most common disease and are refractory to medical treatment in 15% of patients. Currently, temporary relief is achieved with steroid blocks or pulsed radiofrequency ablation, which have short-term benefits. Our project aims to develop a non-invasive treatment for medically refractory chronic migraine, which does not require a permanent implant. This project investigates the safety and effectiveness of pulsed focused ultrasound (FUS) in a validated rodent headache model of cutaneous allodynia associated with chronic migraine (CM) as compared to sumatriptan and ablative lesioning. We demonstrate a significant reduction in mechanical thresholds as measured through Von Frey filaments in CM in the forepaw and periorbital region (p < 0.001). Sumatriptan and pulsed FUS both significantly improve thresholds at day 3 after treatment in the periorbital region. Ablative lesioning has no effect. This study provides initial evidence that FUS may provide an important therapeutic option for patients suffering from CM.

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KW - Focused ultrasound

KW - High intensity focused ultrasound

KW - Mechanical threshold

KW - Occipital nerve

KW - Von Frey

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The use of focused ultrasound for the treatment of cutaneous allodynia associated with chronic migraine

Abstract

Keywords

ASJC Scopus subject areas

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