TY - JOUR
T1 - The translational neuroscience of sleep
T2 - A contextual framework
AU - Grandner, Michael A.
AU - Fernandez, Fabian Xosé
N1 - Publisher Copyright:
© 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works
PY - 2021/10/29
Y1 - 2021/10/29
N2 - Sleep is entwined across many physiologic processes in the brain and periphery, thereby exerting tremendous influence on our well-being. Yet sleep exists in a social-environmental context. Contextualizing sleep health with respect to its determinants-from individual- to societal-level factors-would enable neuroscientists to more effectively translate sleep health into clinical practice. Key challenges and opportunities pertain to (i) recognizing and exploring sleep's functional roles, (ii) clarifying causal mechanisms in relation to key outcomes, (iii) developing richer model systems, (iv) linking models to known contextual factors, and (v) leveraging advances in multisensory technology. Meeting these challenges and opportunities would help transcend disciplinary boundaries such that social-environmental considerations related to sleep would become an ever-greater presence in the clinic.
AB - Sleep is entwined across many physiologic processes in the brain and periphery, thereby exerting tremendous influence on our well-being. Yet sleep exists in a social-environmental context. Contextualizing sleep health with respect to its determinants-from individual- to societal-level factors-would enable neuroscientists to more effectively translate sleep health into clinical practice. Key challenges and opportunities pertain to (i) recognizing and exploring sleep's functional roles, (ii) clarifying causal mechanisms in relation to key outcomes, (iii) developing richer model systems, (iv) linking models to known contextual factors, and (v) leveraging advances in multisensory technology. Meeting these challenges and opportunities would help transcend disciplinary boundaries such that social-environmental considerations related to sleep would become an ever-greater presence in the clinic.
UR - http://www.scopus.com/inward/record.url?scp=85121188142&partnerID=8YFLogxK
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U2 - 10.1126/SCIENCE.ABJ8188
DO - 10.1126/SCIENCE.ABJ8188
M3 - Review article
C2 - 34709899
AN - SCOPUS:85121188142
SN - 0036-8075
VL - 374
SP - 568
EP - 573
JO - Science
JF - Science
IS - 6567
ER -