@article{a62e60e1ff664a53937eb7e7e82c8d49,
title = "The Tousled gene in A. thaliana encodes a protein kinase homolog that is required for leaf and flower development",
abstract = "Mutation at the TOUSLED locus of A. thaliana results in a complex phenotype, the most dramatic aspect of which being the abnormal flowers produced in mutant plants. tsl flowers show a random loss of floral organs, and organ development is impaired. The TSL gene appears to be required in the floral meristem for correct initiation of floral organ primordia and for proper development of organ primordia. Loss of TSL function also affects flowering time and leaf morphology. Using a mutation derived by T-DNA insertion mutagenesis, we have cloned the TSL gene and found that it encodes a protein kinase homolog with a novel N-terminal domain. This protein kinase gene identifies a novel signaling/regulatory pathway used during development in Arabidopsis.",
author = "Roe, {Judith L.} and Rivin, {Carol J.} and Sessions, {R. Allen} and Feldmann, {Kenneth A.} and Zambryski, {Patricia C.}",
note = "Funding Information: We sincerely thank C. Lister, R. Schmidt, and C. Dean for RFLP mapping the TSL gene, A. Lupas for the coiled-coil prediction analysis, D. Pardoe and the electron microscope lab for help with scanning electron microscopy, S. Coomber for the genomic library, D. Meinke and B. Kunkel for identifying the tsl alleles, E. Meyerowitz for cDNA libraries, C. Waddell and M. Honma for the transformation vector, X.-W. Deng for the 18s rDNA plasmid, and I. Sussex and K. Serikawa for critical review of the manuscript. This work was supported by Department of Energygrant 88ER13882to P. C. 2.; J. L. R. wassupported by National Institutes of Health Individual Research Service Award (l-F32-GM13292-01-81-3) and an American Cancer Society postdoctoral fellowship (PF-3826).",
year = "1993",
month = dec,
day = "3",
doi = "10.1016/0092-8674(93)90537-Z",
language = "English (US)",
volume = "75",
pages = "939--950",
journal = "Cell",
issn = "0092-8674",
publisher = "Elsevier B.V.",
number = "5",
}