Abstract
[1-Deamino,4-L-leucine]-oxytocin and [1-deamino,4-L-isoleucine]-oxytocin have been synthesized by the solid phase method, and some of their pharmacological properties have been determined. [1-Deamino,4-L-leucine]-oxytocin was also synthesized by the p-nitrophenyl ester stepwise procedure and compared to that synthesized by the solid phase method. The two preparations were found to be identical. The oxytocic and avian vasodepressor potencies of [1-deamino,4-L-leucine]-oxytocin and [1-deamino,4-L-isoleucine]-oxytocin are two- to threefold higher than those of [4-L-leucine]-oxytocin and [4-L-isoleucine]-oxytocin respectively. The two deamino analogs also exhibit milk-ejecting activities of approximately 150 units/mg. Neither analog possesses appreciable pressor or antidiuretic activity. A similar enhancement of oxytocic and avian vasodepressor activities had been observed when the free amino group of [4-L-valine]-oxytocin was replaced by hydrogen.
Original language | English (US) |
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Pages (from-to) | 677-680 |
Number of pages | 4 |
Journal | Journal of the American Chemical Society |
Volume | 92 |
Issue number | 3 |
DOIs | |
State | Published - Feb 1 1970 |
Externally published | Yes |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry