The solution phase synthesis of diketopiperazine libraries via the Ugi reaction: Novel application of Armstrong's convertible isonitrile.

Christopher Hulme; Matthew M. Morrissette; Francis A. Volz; Christopher J. Burns

doi:10.1016/S0040-4039(97)10795-X

The solution phase synthesis of diketopiperazine libraries via the Ugi reaction: Novel application of Armstrong's convertible isonitrile.

Christopher Hulme
, Matthew M. Morrissette
, Francis A. Volz
, Christopher J. Burns

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

This communication describes the generation of high-yielding solution phase diketopiperazine libraries via a '3-step, 1-pot' procedure, employing the Ugi multi-component reaction (MCR), followed by BOC deprotection and cyclization to diketopiperazine (DKP). Exploitation of Armstrong's convertible isonitrile in the Ugi reaction utilising an 'internal nucleophile' approach for diketopiperazine formation is presented.

Original language	English (US)
Pages (from-to)	1113-1116
Number of pages	4
Journal	Tetrahedron Letters
Volume	39
Issue number	10
DOIs	https://doi.org/10.1016/S0040-4039(97)10795-X
State	Published - Mar 5 1998
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(97)10795-X

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abstract = "This communication describes the generation of high-yielding solution phase diketopiperazine libraries via a '3-step, 1-pot' procedure, employing the Ugi multi-component reaction (MCR), followed by BOC deprotection and cyclization to diketopiperazine (DKP). Exploitation of Armstrong's convertible isonitrile in the Ugi reaction utilising an 'internal nucleophile' approach for diketopiperazine formation is presented.",

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AU - Burns, Christopher J.

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The solution phase synthesis of diketopiperazine libraries via the Ugi reaction: Novel application of Armstrong's convertible isonitrile.

Abstract

ASJC Scopus subject areas

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