TY - JOUR
T1 - The solution phase synthesis of diketopiperazine libraries via the Ugi reaction
T2 - Novel application of Armstrong's convertible isonitrile.
AU - Hulme, Christopher
AU - Morrissette, Matthew M.
AU - Volz, Francis A.
AU - Burns, Christopher J.
PY - 1998/3/5
Y1 - 1998/3/5
N2 - This communication describes the generation of high-yielding solution phase diketopiperazine libraries via a '3-step, 1-pot' procedure, employing the Ugi multi-component reaction (MCR), followed by BOC deprotection and cyclization to diketopiperazine (DKP). Exploitation of Armstrong's convertible isonitrile in the Ugi reaction utilising an 'internal nucleophile' approach for diketopiperazine formation is presented.
AB - This communication describes the generation of high-yielding solution phase diketopiperazine libraries via a '3-step, 1-pot' procedure, employing the Ugi multi-component reaction (MCR), followed by BOC deprotection and cyclization to diketopiperazine (DKP). Exploitation of Armstrong's convertible isonitrile in the Ugi reaction utilising an 'internal nucleophile' approach for diketopiperazine formation is presented.
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U2 - 10.1016/S0040-4039(97)10795-X
DO - 10.1016/S0040-4039(97)10795-X
M3 - Article
AN - SCOPUS:0032485439
SN - 0040-4039
VL - 39
SP - 1113
EP - 1116
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 10
ER -