Abstract
The transcription factor Yin Yang 1 (YY1) is a ubiquitously expressed protein involved in several biological functions, including embryogenesis, differentiation, replication, and cellular proliferation. YY1 can both activate and repress transcription depending on its interactions with other transcription factors and co-factors. It affects the transcription of a large number of mammalian and viral genes. In this review, we focus on the role of YY1 in cancer biology, including its expression, function, regulation by other upstream factors, and some of its more significant downstream effectors. We also discuss its context-dependent and tumor-specific role in human cancer progression, roles as a prognostic marker, and how its interactions with other cancer-associated factors can be exploited to develop novel targeted therapies.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 13-21 |
| Number of pages | 9 |
| Journal | Critical reviews in oncogenesis |
| Volume | 22 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - 2017 |
| Externally published | Yes |
Keywords
- Androgen
- Cancer-associated functions
- Cancer-associated mechanisms
- Expression in cancer
- Transcription regulator
- YY1
ASJC Scopus subject areas
- Cancer Research
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