The Role of Targeted Therapy in the Management of Sinonasal Malignancies

Lawrence Kashat, Christopher H. Le, Alexander G Chiu

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Cancers develop secondary to genetic and epigenetic changes that provide the cell with a survival advantage that promotes cellular immortality. Malignancy arises when tumors use mechanisms to evade detection and destruction by the immune system. Many malignancies seem to elicit an immune response, yet somehow manage to avoid destruction by the cells of the immune system. Cancers may evade this immune response by numerous mechanisms. Several targeted immune therapies are available that block some of these inhibitory signals and enhance the cell-mediated immune response. Many of these agents hold significant promise for future treatment of sinonasal and ventral skull base malignancies.

Original languageEnglish (US)
Pages (from-to)443-455
Number of pages13
JournalOtolaryngologic Clinics of North America
Issue number2
StatePublished - Apr 1 2017


  • Cell-mediated immunity
  • Head and neck melanoma
  • Head and neck squamous cell carcinoma
  • Immunotherapy
  • Mucosal melanoma
  • Sinonasal malignancy
  • Sinonasal tumors
  • Targeted therapy

ASJC Scopus subject areas

  • Otorhinolaryngology


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