The role of SLP-76 and LAT in lymphocyte development

Vadim I. Pivniouk, Raif S. Geha

Research output: Contribution to journalReview articlepeer-review

19 Scopus citations


SLP-76 and LAT are two recently identified adapter proteins that are involved in the signal transduction cascade initiated by engagement of the TCR. The role of these two molecules in thymocyte development has become clearer following studies of gene targeted mice. The data indicate that SLP-76 and LAT are each critical for the expansion and differentiation of double-negative thymocytes and that SLP-76 is essential for allelic exclusion at the TCRβ locus.

Original languageEnglish (US)
Pages (from-to)173-178
Number of pages6
JournalCurrent Opinion in Immunology
Issue number2
StatePublished - Apr 1 2000

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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