The role of SLP-76 and LAT in lymphocyte development

Vadim I. Pivniouk; Raif S. Geha

doi:10.1016/S0952-7915(99)00068-0

The role of SLP-76 and LAT in lymphocyte development

Vadim I. Pivniouk, Raif S. Geha

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

SLP-76 and LAT are two recently identified adapter proteins that are involved in the signal transduction cascade initiated by engagement of the TCR. The role of these two molecules in thymocyte development has become clearer following studies of gene targeted mice. The data indicate that SLP-76 and LAT are each critical for the expansion and differentiation of double-negative thymocytes and that SLP-76 is essential for allelic exclusion at the TCRβ locus.

Original language	English (US)
Pages (from-to)	173-178
Number of pages	6
Journal	Current Opinion in Immunology
Volume	12
Issue number	2
DOIs	https://doi.org/10.1016/S0952-7915(99)00068-0
State	Published - Apr 1 2000
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1016/S0952-7915(99)00068-0

Cite this

@article{33d7868c856c42c2a302ca61687e2b65,

title = "The role of SLP-76 and LAT in lymphocyte development",

abstract = "SLP-76 and LAT are two recently identified adapter proteins that are involved in the signal transduction cascade initiated by engagement of the TCR. The role of these two molecules in thymocyte development has become clearer following studies of gene targeted mice. The data indicate that SLP-76 and LAT are each critical for the expansion and differentiation of double-negative thymocytes and that SLP-76 is essential for allelic exclusion at the TCRβ locus.",

author = "Pivniouk, {Vadim I.} and Geha, {Raif S.}",

note = "Funding Information: RSG is supported by National Institutes of Health grant AI-35714 and by grants from Baxter Healthcare, Caremark and Olsten Corporations. VIP is a recipient of the Charles A King Trust Fellowship Award. ",

year = "2000",

month = apr,

day = "1",

doi = "10.1016/S0952-7915(99)00068-0",

language = "English (US)",

volume = "12",

pages = "173--178",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

publisher = "Elsevier Ltd",

number = "2",

}

TY - JOUR

T1 - The role of SLP-76 and LAT in lymphocyte development

AU - Pivniouk, Vadim I.

AU - Geha, Raif S.

N1 - Funding Information: RSG is supported by National Institutes of Health grant AI-35714 and by grants from Baxter Healthcare, Caremark and Olsten Corporations. VIP is a recipient of the Charles A King Trust Fellowship Award.

PY - 2000/4/1

Y1 - 2000/4/1

N2 - SLP-76 and LAT are two recently identified adapter proteins that are involved in the signal transduction cascade initiated by engagement of the TCR. The role of these two molecules in thymocyte development has become clearer following studies of gene targeted mice. The data indicate that SLP-76 and LAT are each critical for the expansion and differentiation of double-negative thymocytes and that SLP-76 is essential for allelic exclusion at the TCRβ locus.

AB - SLP-76 and LAT are two recently identified adapter proteins that are involved in the signal transduction cascade initiated by engagement of the TCR. The role of these two molecules in thymocyte development has become clearer following studies of gene targeted mice. The data indicate that SLP-76 and LAT are each critical for the expansion and differentiation of double-negative thymocytes and that SLP-76 is essential for allelic exclusion at the TCRβ locus.

UR - http://www.scopus.com/inward/record.url?scp=0034093661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034093661&partnerID=8YFLogxK

U2 - 10.1016/S0952-7915(99)00068-0

DO - 10.1016/S0952-7915(99)00068-0

M3 - Review article

C2 - 10712938

AN - SCOPUS:0034093661

SN - 0952-7915

VL - 12

SP - 173

EP - 178

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 2

ER -

The role of SLP-76 and LAT in lymphocyte development

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this