The role of leiomodin in actin dynamics: a new road or a secret gate

Dmitri Tolkatchev, Carol C. Gregorio, Alla S. Kostyukova

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Leiomodin is an important emerging regulator of thin filaments. As novel molecular, cellular, animal model, and human data accumulate, the mechanisms of its action become clearer. Structural studies played a significant part in understanding the functional significance of leiomodin’s interacting partners and functional domains. In this review, we present the current state of knowledge on the structural and cellular properties of leiomodin which has led to two proposed mechanisms of its function. Although it is known that leiomodin is essential for life, numerous domains within leiomodin remain unstudied and as such, we outline future directions for investigations that we predict will provide evidence that leiomodin is a multifunctional protein.

Original languageEnglish (US)
Pages (from-to)6119-6131
Number of pages13
JournalFEBS Journal
Issue number20
StatePublished - Oct 2022


  • actin
  • leiomodin
  • sarcomeres
  • tropomodulin
  • tropomyosin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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