Abstract
Asthma, a complex, chronic disease characterized by airway inflammation, hyperresponsiveness and remodelling, affects over 300 million people worldwide. While the disease is typically associated with exaggerated allergen-induced type 2 immune responses, these responses are strongly influenced by environmental exposures that stimulate innate immune pathways capable of promoting or protecting from asthma. The dual role played by innate immunity in asthma pathogenesis offers multiple opportunities for both research and clinical interventions and is the subject of this review.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 282-290 |
| Number of pages | 9 |
| Journal | Clinical and Experimental Allergy |
| Volume | 50 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2020 |
Keywords
- asthma
- environment
- farm effect
- hygiene hypothesis
- innate immunity
- microbiome
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology