Abstract
Cytomegalovirus (CMV) is one of the most ubiquitous human latent persistent viruses. While this virus can be highly harmful and even deadly to the developing fetus and to severely immunocompromised individuals, it appears to be overtly well tolerated and compatible with long life in the vast majority of infected individuals. However, several epidemiological studies have linked CMV to metabolic disturbances, obesity, diabetes, cardiovascular diseases, frailty, and other chronic diseases. CMV was also proposed to be a potentially causal factor for some manifestations of immune aging, including an accumulation of highly differentiated T cells and potential increase in subclinical systemic inflammation. Given that many of the earlier mentioned issues have not been conclusively and mechanistically settled, this chapter will discuss our current understanding of the impact of CMV on the aging of the immune system and of the whole organism.
| Original language | English (US) |
|---|---|
| Title of host publication | Human Aging |
| Subtitle of host publication | From Cellular Mechanisms to Therapeutic Strategies |
| Publisher | Elsevier |
| Pages | 319-328 |
| Number of pages | 10 |
| ISBN (Electronic) | 9780128225691 |
| DOIs | |
| State | Published - Jan 1 2021 |
| Externally published | Yes |
Keywords
- Chronic diseases
- Cytomegalovirus
- Host immune response
- Immune aging
- Inflammation
- Longevity
ASJC Scopus subject areas
- General Medicine