The role of cytomegalovirus in organismal and immune aging

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Cytomegalovirus (CMV) is one of the most ubiquitous human latent persistent viruses. While this virus can be highly harmful and even deadly to the developing fetus and to severely immunocompromised individuals, it appears to be overtly well tolerated and compatible with long life in the vast majority of infected individuals. However, several epidemiological studies have linked CMV to metabolic disturbances, obesity, diabetes, cardiovascular diseases, frailty, and other chronic diseases. CMV was also proposed to be a potentially causal factor for some manifestations of immune aging, including an accumulation of highly differentiated T cells and potential increase in subclinical systemic inflammation. Given that many of the earlier mentioned issues have not been conclusively and mechanistically settled, this chapter will discuss our current understanding of the impact of CMV on the aging of the immune system and of the whole organism.

Original languageEnglish (US)
Title of host publicationHuman Aging
Subtitle of host publicationFrom Cellular Mechanisms to Therapeutic Strategies
Number of pages10
ISBN (Electronic)9780128225691
StatePublished - Jan 1 2021
Externally publishedYes


  • Chronic diseases
  • Cytomegalovirus
  • Host immune response
  • Immune aging
  • Inflammation
  • Longevity

ASJC Scopus subject areas

  • General Medicine


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