The role of calcium ions in the suppression of the photoresponse during anoxia and application of metabolic inhibitors

Fulton Wong; R. Clark Lantz; Alexander Mauro

doi:10.1016/0042-6989(79)90170-6

The role of calcium ions in the suppression of the photoresponse during anoxia and application of metabolic inhibitors

Fulton Wong, R. Clark Lantz, Alexander Mauro

Cellular and Molecular Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

In these experiments, it was found that anoxia could abolish (reversibly) the generator potential of Limulus ventral photoreceptors in the absence of extracellular calcium. When the photoreceptors were poisoned with the metabolic inhibitor DNP, which has similar effects to anoxia, it was found that intracellular injection of the calcium chelator EGTA could restore the amplitude of the generator potential. Anoxia and DNP may exert their effects by raising the intracellular calcium ion concentration.

Original language	English (US)
Pages (from-to)	251-254
Number of pages	4
Journal	Vision Research
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/0042-6989(79)90170-6
State	Published - 1979

Keywords

Ca
DNP
anoxia
photoreceptors

ASJC Scopus subject areas

Ophthalmology
Sensory Systems

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10.1016/0042-6989(79)90170-6

Cite this

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title = "The role of calcium ions in the suppression of the photoresponse during anoxia and application of metabolic inhibitors",

abstract = "In these experiments, it was found that anoxia could abolish (reversibly) the generator potential of Limulus ventral photoreceptors in the absence of extracellular calcium. When the photoreceptors were poisoned with the metabolic inhibitor DNP, which has similar effects to anoxia, it was found that intracellular injection of the calcium chelator EGTA could restore the amplitude of the generator potential. Anoxia and DNP may exert their effects by raising the intracellular calcium ion concentration.",

keywords = "Ca, DNP, anoxia, photoreceptors",

author = "Fulton Wong and Lantz, {R. Clark} and Alexander Mauro",

note = "Funding Information: Acknu~lr~yrmunts-F.Ww.a ss upportedb y grants from the NIH to Floyd Ratliff and by a graduatef ellowship from the RockefellerU niversity.R .C.L. was supportedb ; USPHS PostdoctoralF ellowshiuE Y05090-01D. raeonflies used in theses tudiesw eres uppiiedb y Dr Richard-Chap-pell. The housefliesa nd fleshflies were supplied by Dr Roger Zimmerman.",

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doi = "10.1016/0042-6989(79)90170-6",

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AU - Lantz, R. Clark

AU - Mauro, Alexander

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PY - 1979

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N2 - In these experiments, it was found that anoxia could abolish (reversibly) the generator potential of Limulus ventral photoreceptors in the absence of extracellular calcium. When the photoreceptors were poisoned with the metabolic inhibitor DNP, which has similar effects to anoxia, it was found that intracellular injection of the calcium chelator EGTA could restore the amplitude of the generator potential. Anoxia and DNP may exert their effects by raising the intracellular calcium ion concentration.

AB - In these experiments, it was found that anoxia could abolish (reversibly) the generator potential of Limulus ventral photoreceptors in the absence of extracellular calcium. When the photoreceptors were poisoned with the metabolic inhibitor DNP, which has similar effects to anoxia, it was found that intracellular injection of the calcium chelator EGTA could restore the amplitude of the generator potential. Anoxia and DNP may exert their effects by raising the intracellular calcium ion concentration.

KW - Ca

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KW - anoxia

KW - photoreceptors

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The role of calcium ions in the suppression of the photoresponse during anoxia and application of metabolic inhibitors

Abstract

Keywords

ASJC Scopus subject areas

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