The role of b cell abnormalities in the systemic autoimmune syndromes of lpr and gld mice

Robert A. Eisenberg; Eric S. Sobel; Elizabeth A. Reap; Melissa D. Halpern; Philip L. Cohen

doi:10.1006/smim.1994.1008

The role of b cell abnormalities in the systemic autoimmune syndromes of lpr and gld mice

Robert A. Eisenberg, Eric S. Sobel, Elizabeth A. Reap, Melissa D. Halpern, Philip L. Cohen

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

B cell abnormalities play a central role in the systemic autoimmune syndromes of lpr and gld mice. In the lpr model, autoantibody production requires the intrinsic expression of the lpr gene in B cells, while in the gld mouse the genetic defect is extrinsic, yet probably results in a similar failure of B cell tolerance. Despite their abnormality, lpr B cells require lpr (abnormal) T cells in order to produce autoantibodies.

Original language	English (US)
Pages (from-to)	49-54
Number of pages	6
Journal	Seminars in Immunology
Volume	6
Issue number	1
DOIs	https://doi.org/10.1006/smim.1994.1008
State	Published - Feb 1994
Externally published	Yes

Keywords

B cells
Chimera
Gld
Lpr
Tolerance

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1006/smim.1994.1008

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abstract = "B cell abnormalities play a central role in the systemic autoimmune syndromes of lpr and gld mice. In the lpr model, autoantibody production requires the intrinsic expression of the lpr gene in B cells, while in the gld mouse the genetic defect is extrinsic, yet probably results in a similar failure of B cell tolerance. Despite their abnormality, lpr B cells require lpr (abnormal) T cells in order to produce autoantibodies.",

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The role of b cell abnormalities in the systemic autoimmune syndromes of lpr and gld mice

Abstract

Keywords

ASJC Scopus subject areas

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