The rise and fall of the ancient northern pike master sex determining gene

Qiaowei Pan; Romain Feron; Elodie Jouanno; Hugo Darras; Amaury Herpin; Ben Koop; Eric Rondeau; Frederick W. Goetz; Wesley A. Larson; Louis Bernatchez; Mike Tringali; Stephen S. Curran; Eric Saillant; Gael P.J. Denys; Frank A. von Hippel; Songlin Chen; J. Andrés López; Hugo Verreycken; Konrad Ocalewicz; Rene Guyomard; Camille Eche; Jerome Lluch; Celine Roques; Hongxia Hu; Roger Tabor; Patrick Dehaan; Krista M. Nichols; Laurent Journot; Hugues Parrinello; Christophe Klopp; Elena A. Interesova; Vladimir Trifonov; Manfred Schartl; John Postlethwait; Yann Guiguen

doi:10.7554/eLife.62858

The rise and fall of the ancient northern pike master sex determining gene

Qiaowei Pan
, Romain Feron
, Elodie Jouanno
, Hugo Darras
, Amaury Herpin
, Ben Koop
, Eric Rondeau
, Frederick W. Goetz
, Wesley A. Larson
, Louis Bernatchez
, Mike Tringali
, Stephen S. Curran
, Eric Saillant
, Gael P.J. Denys
, Frank A. von Hippel
, Songlin Chen
, J. Andrés López
, Hugo Verreycken
, Konrad Ocalewicz
, Rene Guyomard

Camille Eche, Jerome Lluch, Celine Roques, Hongxia Hu, Roger Tabor, Patrick Dehaan, Krista M. Nichols, Laurent Journot, Hugues Parrinello, Christophe Klopp, Elena A. Interesova, Vladimir Trifonov, Manfred Schartl, John Postlethwait, Yann Guiguen

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

The understanding of the evolution of variable sex determination mechanisms across taxa requires comparative studies among closely related species. Following the fate of a known master sex-determining gene, we traced the evolution of sex determination in an entire teleost order (Esociformes). We discovered that the northern pike (Esox lucius) master sex-determining gene originated from a 65 to 90 million-year-old gene duplication event and that it remained sex-linked on undifferentiated sex chromosomes for at least 56 million years in multiple species. We identified several independent species-or population-specific sex determination transitions, including a recent loss of a Y-chromosome. These findings highlight the diversity of evolutionary fates of master sex-determining genes and the importance of population demographic history in sex determination studies. We hypothesize that occasional sex reversals and genetic bottlenecks provide a non-adaptive explanation for sex determination transitions.

Original language	English (US)
Pages (from-to)	1-50
Number of pages	50
Journal	eLife
Volume	10
DOIs	https://doi.org/10.7554/eLife.62858
State	Published - Jan 2021
Externally published	Yes

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
General Immunology and Microbiology

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Pan, Q., Feron, R., Jouanno, E., Darras, H., Herpin, A., Koop, B., Rondeau, E., Goetz, F. W., Larson, W. A., Bernatchez, L., Tringali, M., Curran, S. S., Saillant, E., Denys, G. P. J., von Hippel, F. A., Chen, S., López, J. A., Verreycken, H., Ocalewicz, K., ... Guiguen, Y. (2021). The rise and fall of the ancient northern pike master sex determining gene. eLife, 10, 1-50. https://doi.org/10.7554/eLife.62858

Pan, Q, Feron, R, Jouanno, E, Darras, H, Herpin, A, Koop, B, Rondeau, E, Goetz, FW, Larson, WA, Bernatchez, L, Tringali, M, Curran, SS, Saillant, E, Denys, GPJ, von Hippel, FA, Chen, S, López, JA, Verreycken, H, Ocalewicz, K, Guyomard, R, Eche, C, Lluch, J, Roques, C, Hu, H, Tabor, R, Dehaan, P, Nichols, KM, Journot, L, Parrinello, H, Klopp, C, Interesova, EA, Trifonov, V, Schartl, M, Postlethwait, J & Guiguen, Y 2021, 'The rise and fall of the ancient northern pike master sex determining gene', eLife, vol. 10, pp. 1-50. https://doi.org/10.7554/eLife.62858

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title = "The rise and fall of the ancient northern pike master sex determining gene",

abstract = "The understanding of the evolution of variable sex determination mechanisms across taxa requires comparative studies among closely related species. Following the fate of a known master sex-determining gene, we traced the evolution of sex determination in an entire teleost order (Esociformes). We discovered that the northern pike (Esox lucius) master sex-determining gene originated from a 65 to 90 million-year-old gene duplication event and that it remained sex-linked on undifferentiated sex chromosomes for at least 56 million years in multiple species. We identified several independent species-or population-specific sex determination transitions, including a recent loss of a Y-chromosome. These findings highlight the diversity of evolutionary fates of master sex-determining genes and the importance of population demographic history in sex determination studies. We hypothesize that occasional sex reversals and genetic bottlenecks provide a non-adaptive explanation for sex determination transitions.",

author = "Qiaowei Pan and Romain Feron and Elodie Jouanno and Hugo Darras and Amaury Herpin and Ben Koop and Eric Rondeau and Goetz, \{Frederick W.\} and Larson, \{Wesley A.\} and Louis Bernatchez and Mike Tringali and Curran, \{Stephen S.\} and Eric Saillant and Denys, \{Gael P.J.\} and \{von Hippel\}, \{Frank A.\} and Songlin Chen and L{\'o}pez, \{J. Andr{\'e}s\} and Hugo Verreycken and Konrad Ocalewicz and Rene Guyomard and Camille Eche and Jerome Lluch and Celine Roques and Hongxia Hu and Roger Tabor and Patrick Dehaan and Nichols, \{Krista M.\} and Laurent Journot and Hugues Parrinello and Christophe Klopp and Interesova, \{Elena A.\} and Vladimir Trifonov and Manfred Schartl and John Postlethwait and Yann Guiguen",

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AU - Koop, Ben

AU - Rondeau, Eric

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AU - López, J. Andrés

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AU - Ocalewicz, Konrad

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AU - Eche, Camille

AU - Lluch, Jerome

AU - Roques, Celine

AU - Hu, Hongxia

AU - Tabor, Roger

AU - Dehaan, Patrick

AU - Nichols, Krista M.

AU - Journot, Laurent

AU - Parrinello, Hugues

AU - Klopp, Christophe

AU - Interesova, Elena A.

AU - Trifonov, Vladimir

AU - Schartl, Manfred

AU - Postlethwait, John

AU - Guiguen, Yann

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The rise and fall of the ancient northern pike master sex determining gene

Abstract

ASJC Scopus subject areas

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