@article{9c43f122a59f4db0ad420ef4610268de,
title = "The rise and fall of the ancient northern pike master sex determining gene",
abstract = "The understanding of the evolution of variable sex determination mechanisms across taxa requires comparative studies among closely related species. Following the fate of a known master sex-determining gene, we traced the evolution of sex determination in an entire teleost order (Esociformes). We discovered that the northern pike (Esox lucius) master sex-determining gene originated from a 65 to 90 million-year-old gene duplication event and that it remained sex-linked on undifferentiated sex chromosomes for at least 56 million years in multiple species. We identified several independent species-or population-specific sex determination transitions, including a recent loss of a Y-chromosome. These findings highlight the diversity of evolutionary fates of master sex-determining genes and the importance of population demographic history in sex determination studies. We hypothesize that occasional sex reversals and genetic bottlenecks provide a non-adaptive explanation for sex determination transitions.",
author = "Qiaowei Pan and Romain Feron and Elodie Jouanno and Hugo Darras and Amaury Herpin and Ben Koop and Eric Rondeau and Goetz, {Frederick W.} and Larson, {Wesley A.} and Louis Bernatchez and Mike Tringali and Curran, {Stephen S.} and Eric Saillant and Denys, {Gael P.J.} and {von Hippel}, {Frank A.} and Songlin Chen and L{\'o}pez, {J. Andr{\'e}s} and Hugo Verreycken and Konrad Ocalewicz and Rene Guyomard and Camille Eche and Jerome Lluch and Celine Roques and Hongxia Hu and Roger Tabor and Patrick Dehaan and Nichols, {Krista M.} and Laurent Journot and Hugues Parrinello and Christophe Klopp and Interesova, {Elena A.} and Vladimir Trifonov and Manfred Schartl and John Postlethwait and Yann Guiguen",
note = "Funding Information: We are grateful to the fish facility of INRAE LPGP for support in experimental installation and fish maintenance and to the GenoToul bioinformatics platform Toulouse Midi-Pyrenees (Bioinfo GenoToul) for providing help, computing and storage resources. This work was supported by the Agence Nationale de la Recherche, the Deutsche Forschungsgemeinschaft (ANR/DFG, PhyloSex project, 2014-2016, SCHA 408/10-1, to Y.G and M.S), and the U.S. National Institutes of Health (R01GM085318 to J.H.P). The MGX and Get-Plage core sequencing facilities were supported by France Genomique National infrastructure, funded as part of the “Investissement d{\textquoteright}avenir” program managed by the Agence Nationale pour la Recherche (contract ANR-10-INBS-09). We thank the MNHN curators for providing access to the collections of E. aquitanicus and E. cisalpinus and for the ONEMA. We thank G.B. Delmastro for help with specimen sampling. We also thank Mackenzie Garvey and Penny Swanson for assistance with dissection of N. hubbsi. Funding Information: We are grateful to the fish facility of INRAE LPGP for support in experimental installation and fish maintenance and to the GenoToul bioinformatics platform Toulouse Midi-Pyrenees (Bioinfo GenoToul) for providing help, computing and storage resources. This work was supported by the Agence Nationale de la Recherche, the Deutsche Forschungsgemeinschaft (ANR/DFG, PhyloSex project, 2014-2016, SCHA 408/10-1, to Y.G and M.S), and the U.S. National Institutes of Health (R01GM085318 to J.H.P). The MGX and Get-Plage core sequencing facilities were supported by France Genomique National infrastructure, funded as part of the ?Investissement d?avenir? program managed by the Agence Nationale pour la Recherche (contract ANR-10-INBS-09). We thank the MNHN curators for providing access to the collections of E. aquitanicus and E. cisalpinus and for the ONEMA. We thank G.B. Delmastro for help with specimen sampling. We also thank Mackenzie Garvey and Penny Swanson for assistance with dissection of N. hubbsi. Publisher Copyright: {\textcopyright} 2021, eLife Sciences Publications Ltd. All rights reserved.",
year = "2021",
month = jan,
doi = "10.7554/eLife.62858",
language = "English (US)",
volume = "10",
pages = "1--50",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",
}