TY - JOUR
T1 - The relationship of the major murine histocompatibility region associated IA antigens to mitogen responses
AU - Niederhuber, John E.
AU - Frelinger, Jeffrey A.
AU - Dugan, Elizabeth
AU - Shreffler, Donald C.
N1 - Funding Information:
‘Supported by Damon Runyon DRG-1260, Michigan Kidney Foundation, and NIH Grants Rot-AI-1 1962-01 and ROl-AI-12153-01. ‘Present address: Department of Microbiology, The University of Michigan Medical Center, Ann Arbor, Mich. 48 104. 3Recipient of U.S. Public Health Service Research Career Development Award. ‘Fellow of the Jane Coffin Childs Memorial Fund for Medical Research.
PY - 1976/6
Y1 - 1976/6
N2 - Genes located in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on subpopulations of T and B cells. Specific anti-Ia serum plus rabbit complement removed the B-lymphocyte population responsive to the mitogen LPS and the subpopulation of T cells responsive to Con-A. Lymphocytes sensitive to PHA or leucoagglutinin were not removed by anti-Ia serum and complement. Significant inhibition of the proliferative response to LPS was also obtained by brief periods of cell pretreatment with anti-Ia antibodies without complement. This inhibition was specific with the appropriate anti-Ia serum and did not occur with anti-H-2K sera or when cells of a different I region were pretreated.
AB - Genes located in the I region of the H-2 complex control a system of lymphocyte alloantigens (Ia) which are expressed on subpopulations of T and B cells. Specific anti-Ia serum plus rabbit complement removed the B-lymphocyte population responsive to the mitogen LPS and the subpopulation of T cells responsive to Con-A. Lymphocytes sensitive to PHA or leucoagglutinin were not removed by anti-Ia serum and complement. Significant inhibition of the proliferative response to LPS was also obtained by brief periods of cell pretreatment with anti-Ia antibodies without complement. This inhibition was specific with the appropriate anti-Ia serum and did not occur with anti-H-2K sera or when cells of a different I region were pretreated.
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U2 - 10.1016/0022-4804(76)90091-3
DO - 10.1016/0022-4804(76)90091-3
M3 - Article
C2 - 59005
AN - SCOPUS:0017186164
SN - 0022-4804
VL - 20
SP - 563
EP - 570
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 6
ER -