TY - JOUR
T1 - The relationship of dietary lipid intake and age-related macular degeneration in a case-control study
T2 - AREDS report no. 20
AU - SanGiovanni, John Paul
AU - Chew, Emily Y.
AU - Clemons, Traci E.
AU - Davis, Matthew D.
AU - Ferris, Frederick L.
AU - Gensler, Gary R.
AU - Kurinij, Natalie
AU - Lindblad, Anne S.
AU - Milton, Roy C.
AU - Seddon, Johanna M.
AU - Sperduto Md, Robert D.
PY - 2007/5
Y1 - 2007/5
N2 - Objective: To evaluate the association of lipid intake with baseline severity of age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS). Methods: Age-Related Eye Disease Study participants aged 60 to 80 years at enrollment (N=4519) provided estimates of habitual nutrient intake through a self-administered semiquantitative food frequency questionnaire. Stereoscopic color fundus photographs were used to categorize participants into 4 AMD severity groups and a control group (participants with <15 small drusen). Results: Dietary total ω-3 long-chain polyunsaturated fatty acid (LCPUFA) intake was inversely associated with neovascular (NV) AMD (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.41-0.90), as was docosahexaenoic acid, a retinal ω-3 LCPUFA (OR, 0.54; 95% CI, 0.36-0.80), comparing highest vs lowest quintile of intake, after adjustment for total energy intake and covariates. Higher fish consumption, both total and broiled/baked, was also inversely associated with NV AMD (OR, 0.61; 95% CI, 0.37-1.00 and OR, 0.65; 95% CI, 0.45-0.93, respectively). Dietary arachidonic acid was directly associated with NV AMD prevalence (OR, 1.54; 95% CI, 1.04-2.29). No statistically significant relationships existed for the other lipids or AMD groups. Conclusion: Higher intake of ω-3 LCPUFAs and fish was associated with decreased likelihood of having NV AMD.
AB - Objective: To evaluate the association of lipid intake with baseline severity of age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS). Methods: Age-Related Eye Disease Study participants aged 60 to 80 years at enrollment (N=4519) provided estimates of habitual nutrient intake through a self-administered semiquantitative food frequency questionnaire. Stereoscopic color fundus photographs were used to categorize participants into 4 AMD severity groups and a control group (participants with <15 small drusen). Results: Dietary total ω-3 long-chain polyunsaturated fatty acid (LCPUFA) intake was inversely associated with neovascular (NV) AMD (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.41-0.90), as was docosahexaenoic acid, a retinal ω-3 LCPUFA (OR, 0.54; 95% CI, 0.36-0.80), comparing highest vs lowest quintile of intake, after adjustment for total energy intake and covariates. Higher fish consumption, both total and broiled/baked, was also inversely associated with NV AMD (OR, 0.61; 95% CI, 0.37-1.00 and OR, 0.65; 95% CI, 0.45-0.93, respectively). Dietary arachidonic acid was directly associated with NV AMD prevalence (OR, 1.54; 95% CI, 1.04-2.29). No statistically significant relationships existed for the other lipids or AMD groups. Conclusion: Higher intake of ω-3 LCPUFAs and fish was associated with decreased likelihood of having NV AMD.
UR - http://www.scopus.com/inward/record.url?scp=34248522853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34248522853&partnerID=8YFLogxK
U2 - 10.1001/archopht.125.5.671
DO - 10.1001/archopht.125.5.671
M3 - Article
C2 - 17502507
AN - SCOPUS:34248522853
SN - 0003-9950
VL - 125
SP - 671
EP - 679
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 5
ER -