The relationship of dietary lipid intake and age-related macular degeneration in a case-control study: AREDS report no. 20

John Paul SanGiovanni, Emily Y. Chew, Traci E. Clemons, Matthew D. Davis, Frederick L. Ferris, Gary R. Gensler, Natalie Kurinij, Anne S. Lindblad, Roy C. Milton, Johanna M. Seddon, Robert D. Sperduto Md

Research output: Contribution to journalArticlepeer-review

239 Scopus citations

Abstract

Objective: To evaluate the association of lipid intake with baseline severity of age-related macular degeneration (AMD) in the Age-Related Eye Disease Study (AREDS). Methods: Age-Related Eye Disease Study participants aged 60 to 80 years at enrollment (N=4519) provided estimates of habitual nutrient intake through a self-administered semiquantitative food frequency questionnaire. Stereoscopic color fundus photographs were used to categorize participants into 4 AMD severity groups and a control group (participants with <15 small drusen). Results: Dietary total ω-3 long-chain polyunsaturated fatty acid (LCPUFA) intake was inversely associated with neovascular (NV) AMD (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.41-0.90), as was docosahexaenoic acid, a retinal ω-3 LCPUFA (OR, 0.54; 95% CI, 0.36-0.80), comparing highest vs lowest quintile of intake, after adjustment for total energy intake and covariates. Higher fish consumption, both total and broiled/baked, was also inversely associated with NV AMD (OR, 0.61; 95% CI, 0.37-1.00 and OR, 0.65; 95% CI, 0.45-0.93, respectively). Dietary arachidonic acid was directly associated with NV AMD prevalence (OR, 1.54; 95% CI, 1.04-2.29). No statistically significant relationships existed for the other lipids or AMD groups. Conclusion: Higher intake of ω-3 LCPUFAs and fish was associated with decreased likelihood of having NV AMD.

Original languageEnglish (US)
Pages (from-to)671-679
Number of pages9
JournalArchives of Ophthalmology
Volume125
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

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