The rebirth of neuroscience in psychosomatic medicine, part II: Clinical applications and implications for research

Richard D. Lane, Shari R. Waldstein, Hugo D. Critchley, Stuart W.G. Derbyshire, Douglas A. Drossman, Tor D. Wager, Neil Schneiderman, Margaret A. Chesney, J. Richard Jennings, William R. Lovallo, Robert M. Rose, Julian F. Thayer, Oliver G. Cameron

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations


During the second half of the last century, biopsychosocial research in psychosomatic medicine largely ignored the brain. Neuroscience has started to make a comeback in psychosomatic medicine research and promises to advance the field in important ways. In this paper we briefly review select brain imaging research findings in psychosomatic medicine in four key areas: cardiovascular regulation, visceral pain in the context of functional gastrointestinal disorders, acute and chronic somatic pain and placebo. In each area, there is a growing literature that is beginning to define a network of brain areas that participate in the functions in question. Evidence to date suggests that cortical and subcortical areas that are involved in emotion and emotion regulation play an important role in each domain. Neuroscientific research is therefore validating findings from previous psychosomatic research and has the potential to extend knowledge by delineating the biological mechanisms that link mind and body more completely and with greater specificity. We conclude with a discussion of the implications of this work for how research in psychosomatic medicine is conducted, the ways in which neuroscientific advances can lead to new clinical applications in psychosomatic contexts, the implications of this work for the field of medicine more generally, and the priorities for research in the next 5 to 10 years.

Original languageEnglish (US)
Pages (from-to)135-151
Number of pages17
JournalPsychosomatic medicine
Issue number2
StatePublished - Feb 2009


  • Anterior cingulate cortex
  • Cardiovascular regulation
  • Emotion
  • Neuroscience
  • Pain
  • Placebo

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health


Dive into the research topics of 'The rebirth of neuroscience in psychosomatic medicine, part II: Clinical applications and implications for research'. Together they form a unique fingerprint.

Cite this