The rationale behind autologous autoimmune hematopoietic stem cell transplant conditioning regimens: Concerns over the use of total-body irradiation in systemic sclerosis

R. K. Burt; K. Kallunian; D. Patel; J. Thomas; A. Yeager; A. Traynor; F. Heipe; R. Arnold; A. Marmont; D. Collier; E. Glatstein; J. Snowden

doi:10.1038/sj.bmt.1704671

The rationale behind autologous autoimmune hematopoietic stem cell transplant conditioning regimens: Concerns over the use of total-body irradiation in systemic sclerosis

R. K. Burt, K. Kallunian, D. Patel, J. Thomas, A. Yeager, A. Traynor, F. Heipe, R. Arnold, A. Marmont, D. Collier, E. Glatstein, J. Snowden

Research output: Contribution to journal › Editorial › peer-review

23 Scopus citations

Abstract

Hematopoietic stem cell transplantation (HSCT) is becoming an increasingly recognized indication for treatment of autoimmune diseases and severe immune-mediated disorders. However, multicenter registry data have demonstrated higher than anticipated early toxicity, approximately 10% for autoimmune diseases in general, and 20-27% for diffuse systemic sclerosis (scleroderma). If uncorrected, this high treatment-related mortality will hinder development of stem cell therapy for immune-mediated diseases. In order to develop safer regimens, we address some pitfalls and concepts involved in design and selection of conditioning regimens for autoimmune diseases in general, and because it is associated with the highest regimen-related toxicity, scleroderma in specific.

Original language	English (US)
Pages (from-to)	745-751
Number of pages	7
Journal	Bone Marrow Transplantation
Volume	34
Issue number	9
DOIs	https://doi.org/10.1038/sj.bmt.1704671
State	Published - 2004
Externally published	Yes

ASJC Scopus subject areas

Hematology
Transplantation

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Burt, R. K., Kallunian, K., Patel, D., Thomas, J., Yeager, A., Traynor, A., Heipe, F., Arnold, R., Marmont, A., Collier, D., Glatstein, E., & Snowden, J. (2004). The rationale behind autologous autoimmune hematopoietic stem cell transplant conditioning regimens: Concerns over the use of total-body irradiation in systemic sclerosis. Bone Marrow Transplantation, 34(9), 745-751. https://doi.org/10.1038/sj.bmt.1704671

Burt, RK, Kallunian, K, Patel, D, Thomas, J, Yeager, A, Traynor, A, Heipe, F, Arnold, R, Marmont, A, Collier, D, Glatstein, E & Snowden, J 2004, 'The rationale behind autologous autoimmune hematopoietic stem cell transplant conditioning regimens: Concerns over the use of total-body irradiation in systemic sclerosis', Bone Marrow Transplantation, vol. 34, no. 9, pp. 745-751. https://doi.org/10.1038/sj.bmt.1704671

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abstract = "Hematopoietic stem cell transplantation (HSCT) is becoming an increasingly recognized indication for treatment of autoimmune diseases and severe immune-mediated disorders. However, multicenter registry data have demonstrated higher than anticipated early toxicity, approximately 10% for autoimmune diseases in general, and 20-27% for diffuse systemic sclerosis (scleroderma). If uncorrected, this high treatment-related mortality will hinder development of stem cell therapy for immune-mediated diseases. In order to develop safer regimens, we address some pitfalls and concepts involved in design and selection of conditioning regimens for autoimmune diseases in general, and because it is associated with the highest regimen-related toxicity, scleroderma in specific.",

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AU - Patel, D.

AU - Thomas, J.

AU - Yeager, A.

AU - Traynor, A.

AU - Heipe, F.

AU - Arnold, R.

AU - Marmont, A.

AU - Collier, D.

AU - Glatstein, E.

AU - Snowden, J.

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AB - Hematopoietic stem cell transplantation (HSCT) is becoming an increasingly recognized indication for treatment of autoimmune diseases and severe immune-mediated disorders. However, multicenter registry data have demonstrated higher than anticipated early toxicity, approximately 10% for autoimmune diseases in general, and 20-27% for diffuse systemic sclerosis (scleroderma). If uncorrected, this high treatment-related mortality will hinder development of stem cell therapy for immune-mediated diseases. In order to develop safer regimens, we address some pitfalls and concepts involved in design and selection of conditioning regimens for autoimmune diseases in general, and because it is associated with the highest regimen-related toxicity, scleroderma in specific.

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The rationale behind autologous autoimmune hematopoietic stem cell transplant conditioning regimens: Concerns over the use of total-body irradiation in systemic sclerosis

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ASJC Scopus subject areas

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