Abstract
In this work we discuss the evidence base implicating ω-3 (ω-3) long-chain polyunsaturated fatty acids (LCPUFAs) and their metabolites as key modulators of factors implicated in pathogenesis and pathophysiology of vascular and neurodegenerative retinal diseases of public health significance. As retinal tissue status of LCPUFAs is modifiable by and dependent upon dietary intake, we discuss the capacity of ω-3 LCPUFAs to act in a protective capacity within number of anti-angiogenic and neuroprotective processes operating in the context of etiopathologic environmental risk factors for these diseases. Our general conclusion is that there is a reasonable basis to suspect that ω-3 LCPUFAs may act in a protective role against ischemia, light-, oxygen-, inflammatory-, or age-associated pathology of the vascular and neural retina.
| Original language | English (US) |
|---|---|
| Title of host publication | The Omega-3 Fatty Acid Deficiency Syndrome |
| Subtitle of host publication | Opportunities for Disease Prevention |
| Publisher | Nova Science Publishers, Inc. |
| Pages | 275-294 |
| Number of pages | 20 |
| ISBN (Print) | 9781624177033 |
| State | Published - Mar 2013 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Medicine