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The putative benzene metabolite 2,3,5-tris(glutathion-S-yl)hydroquinone depletes glutathione, stimulates sphingomyelin turnover, and induces apoptosis in HL-60 cells
Shawn B. Bratton
, Serrine S. Lau
, Terrence J. Monks
Pharmacology and Toxicology
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Article
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peer-review
33
Scopus citations
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Dive into the research topics of 'The putative benzene metabolite 2,3,5-tris(glutathion-S-yl)hydroquinone depletes glutathione, stimulates sphingomyelin turnover, and induces apoptosis in HL-60 cells'. Together they form a unique fingerprint.
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Pharmacology, Toxicology and Pharmaceutical Science
Hydroquinone
100%
Glutathione
100%
Trometamol
100%
Sphingomyelin
100%
Ceramide
85%
Hydrogen Peroxide
42%
Effector Caspase
28%
Catalase
14%
Reactive Oxygen Metabolite
14%
Caspase 3
14%
Magnesium Ion
14%
Promyelocytic Leukemia
14%
Sphingomyelin Phosphodiesterase
14%
Biochemistry, Genetics and Molecular Biology
Glutathione
100%
Metabolite
100%
Sphingomyelin
100%
Ceramide
85%
Hydrogen Peroxide
42%
Enzyme
14%
Electron Transport Chain
14%
Signal Transduction
14%
Catalase
14%
Caspase
14%
Caspase 3
14%
Acid Sphingomyelinase
14%
Sphingomyelin Phosphodiesterase
14%
Neuroscience
Glutathione
100%
Sphingomyelin
100%
Ceramide
85%
Hydrogen Peroxide
42%
Effector Caspase
28%
Caspase 3
14%
Cell Signaling
14%
Reactive Oxygen Species
14%
Catalase
14%
Electron Transport Chain
14%
Sphingomyelin Phosphodiesterase
14%
Keyphrases
Mitochondrial Respiratory Chain
20%
Ceramide Signaling
20%