TY - JOUR
T1 - The promise of copper ionophores as antimicrobials
AU - O'Brien, Henrik
AU - Davoodian, Talish
AU - Johnson, Michael D.L.
N1 - Publisher Copyright:
© 2023 The Author(s)
PY - 2023/10
Y1 - 2023/10
N2 - Antibiotic-resistant microbe-mediated deaths are a major worldwide health issue. Unfortunately, due to microbial adaptation to develop resistance, some antibiotics are nullified early in their usage, and worse, resistance is detected before they can even be prescribed. Copper's toxicity since antiquity against microbes at the host–pathogen interface offers a fascinating weapon to fight antimicrobial resistance. Here, we briefly review why copper is so effective, how drugs that work with copper are effective antimicrobials, and how compounds such as these could reinvigorate investment in antimicrobial development.
AB - Antibiotic-resistant microbe-mediated deaths are a major worldwide health issue. Unfortunately, due to microbial adaptation to develop resistance, some antibiotics are nullified early in their usage, and worse, resistance is detected before they can even be prescribed. Copper's toxicity since antiquity against microbes at the host–pathogen interface offers a fascinating weapon to fight antimicrobial resistance. Here, we briefly review why copper is so effective, how drugs that work with copper are effective antimicrobials, and how compounds such as these could reinvigorate investment in antimicrobial development.
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U2 - 10.1016/j.mib.2023.102355
DO - 10.1016/j.mib.2023.102355
M3 - Review article
C2 - 37406562
AN - SCOPUS:85163996134
SN - 1369-5274
VL - 75
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
M1 - 102355
ER -