The promise of copper ionophores as antimicrobials

Henrik O'Brien, Talish Davoodian, Michael D.L. Johnson

Research output: Contribution to journalReview articlepeer-review


Antibiotic-resistant microbe-mediated deaths are a major worldwide health issue. Unfortunately, due to microbial adaptation to develop resistance, some antibiotics are nullified early in their usage, and worse, resistance is detected before they can even be prescribed. Copper's toxicity since antiquity against microbes at the host–pathogen interface offers a fascinating weapon to fight antimicrobial resistance. Here, we briefly review why copper is so effective, how drugs that work with copper are effective antimicrobials, and how compounds such as these could reinvigorate investment in antimicrobial development.

Original languageEnglish (US)
Article number102355
JournalCurrent Opinion in Microbiology
StatePublished - Oct 2023

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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