TY - JOUR
T1 - The Pipeline embolization device for treatment of intracranial aneurysms
AU - Eller, Jorge L.
AU - Dumont, Travis M.
AU - Sorkin, Grant C.
AU - Mokin, Maxim
AU - Levy, Elad I.
AU - Snyder, Kenneth V.
AU - Hopkins, L. Nelson
AU - Siddiqui, Adnan H.
N1 - Funding Information:
TM Dumont, JL Eller and GC Sorkin report no financial relationships. LN Hopkins receives grant/research support from Toshiba; serves as a consultant to Abbott, Boston Scientific, Cordis, Micrus and Silk Road; holds financial interests in AccessClosure, Augmenix, Boston Scientific, Claret Medical, Endomation, Micrus and Valor Medical; holds a board/trustee/ officer position with Access Closure and Claret Medical; serves on Abbott Vascular’s speakers’ bureau; and has received honoraria from Bard, Boston Scientific, Cleveland Clinic, Complete Conference Management, Cordis, Memorial Health Care System and the Society for Cardiovascular Angiography and Interventions (SCAI). EI Levy receives research grant support, other research support (devices) and honoraria from Boston Scientific and research support from Codman & Shurtleff, Inc. and ev3/Covidien Vascular Therapies; has ownership interests in Intratech Medical Ltd. and Mynx/Access Closure; serves as a consultant on the board of Scientific Advisors to Codman & Shurtleff, Inc.; serves as a consultant per project and/or per hour for Codman & Shurtleff, Inc., ev3/Covidien Vascular Therapies and TheraSyn Sensors, Inc.; and receives fees for carotid stent training from Abbott Vascular and ev3/Covidien Vascular Therapies. EI Levy receives no consulting salary arrangements. All consulting is per project and/or per hour. M Mokin has received an educational grant from Toshiba. AH Siddiqui has received research grants from the National Institutes of Health (co-investigator: NINDS 1R01NS064592-01A1; not related to present device review) and the University at Buffalo (Research Development Award); holds financial interests in Hotspur, Intratech Medical, StimSox, Valor Medical and Blockade Medical; serves as a consultant to Codman & Shurtleff, Inc., Concentric Medical, Covidien Vascular Therapies, GuidePoint Global Consulting, Penumbra, Inc., Stryker Neurovascular and Pulsar Vascular; belongs to the speakers’ bureaus of Codman & Shurtleff, Inc. and Genentech; serves on National Steering Committees for Penumbra, Inc. 3D Separator Trial and Covidien SWIFT PRIME Trial; serves on an advisory board for Codman & Shurtleff and Covidien Vascular Therapies; and has received honoraria from American Association of Neurological Surgeons’ courses, Annual Peripheral Angioplasty and All That Jazz Course, Penumbra, Inc. and from Abbott Vascular and Codman & Shurtleff, Inc. for training other neurointerven-tionists in carotid stenting and for training physicians in endovascular stenting for aneurysms. AH Siddiqui receives no consulting salary arrangements. All consulting is per project and/or per hour. KV Snyder serves as a consultant and a member of the speakers’ bureau for Toshiba and has received honoraria from Toshiba. He serves as a member of the speakers’ bureau for and has received honoraria from ev3 and The Stroke Group.
PY - 2014/3
Y1 - 2014/3
N2 - Flow diversion is a new endovascular technique developed for treatment of intracranial aneurysms. It is based on stent-induced modification of blood flow within and around an aneurysm inflow zone, leading to gradual intra-aneurysmal thrombosis and subsequent atrophy, while preserving flow into the parent vessel and perforating branches. Flow-diversion technique is well-suited for the treatment of large, giant, wide-necked, and fusiform intracranial aneurysms because it does not rely on endosaccular packing with coils but rather on the strategy of placing a stent across the aneurysm "neck" or across the diseased segment of a vessel in case of a fusiform aneurysm. Over time, neointimal endothelium covers the flow diverter such that it becomes incorporated into the parent vessel wall and occludes the aneurysm from the circulation, effectively repairing the diseased parent vessel segment. This report describes in detail the Pipeline embolization device (ev3-Covidien, Irvine, California, USA), its mechanism of action and deployment technique, and reviews the pertinent literature regarding safety, efficacy and potential risks and complications associated with the use of this flow diverter.
AB - Flow diversion is a new endovascular technique developed for treatment of intracranial aneurysms. It is based on stent-induced modification of blood flow within and around an aneurysm inflow zone, leading to gradual intra-aneurysmal thrombosis and subsequent atrophy, while preserving flow into the parent vessel and perforating branches. Flow-diversion technique is well-suited for the treatment of large, giant, wide-necked, and fusiform intracranial aneurysms because it does not rely on endosaccular packing with coils but rather on the strategy of placing a stent across the aneurysm "neck" or across the diseased segment of a vessel in case of a fusiform aneurysm. Over time, neointimal endothelium covers the flow diverter such that it becomes incorporated into the parent vessel wall and occludes the aneurysm from the circulation, effectively repairing the diseased parent vessel segment. This report describes in detail the Pipeline embolization device (ev3-Covidien, Irvine, California, USA), its mechanism of action and deployment technique, and reviews the pertinent literature regarding safety, efficacy and potential risks and complications associated with the use of this flow diverter.
KW - Endovascular treatment
KW - Flow diversion
KW - Intracranial aneurysms
KW - Pipeline embolization device
UR - http://www.scopus.com/inward/record.url?scp=84893762130&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84893762130&partnerID=8YFLogxK
U2 - 10.1586/17434440.2014.877188
DO - 10.1586/17434440.2014.877188
M3 - Article
C2 - 24506298
AN - SCOPUS:84893762130
SN - 1743-4440
VL - 11
SP - 137
EP - 150
JO - Expert Review of Medical Devices
JF - Expert Review of Medical Devices
IS - 2
ER -