The perfect storm: Torsades de Pointes in a child with leukemia

Rochelle Bagatell; Michael Hainstock; Merlin C. Lowe; Brent J. Barber; Ricardo A. Samson

doi:10.1002/pbc.20712

The perfect storm: Torsades de Pointes in a child with leukemia

Rochelle Bagatell, Michael Hainstock, Merlin C. Lowe, Brent J. Barber, Ricardo A. Samson

Pediatrics

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Torsades de Pointes (TdP) is a life-threatening ventricular arrhythmia that can be associated with metabolic abnormalities, exposure to arrhythmogenic medications, and congenital long-QT syndrome. This report describes a patient with ALL and multiple complications of therapy who developed TdP. The patient had no evidence of congenital long-QT syndrome, but a constellation of factors appears to have led to QT prolongation, ventricular ectopy, and TdP. Although the patient suffered cardiac arrest, rapid recognition of TdP and prompt defibrillation resulted in an excellent outcome.

Original language	English (US)
Pages (from-to)	996-999
Number of pages	4
Journal	Pediatric Blood and Cancer
Volume	49
Issue number	7
DOIs	https://doi.org/10.1002/pbc.20712
State	Published - Dec 2007

Keywords

Acute lymphocytic leukemia
Cardiac arrest
Torsades de Pointes
Ventricular arrhythmia

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.20712

Cite this

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abstract = "Torsades de Pointes (TdP) is a life-threatening ventricular arrhythmia that can be associated with metabolic abnormalities, exposure to arrhythmogenic medications, and congenital long-QT syndrome. This report describes a patient with ALL and multiple complications of therapy who developed TdP. The patient had no evidence of congenital long-QT syndrome, but a constellation of factors appears to have led to QT prolongation, ventricular ectopy, and TdP. Although the patient suffered cardiac arrest, rapid recognition of TdP and prompt defibrillation resulted in an excellent outcome.",

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AU - Bagatell, Rochelle

AU - Hainstock, Michael

AU - Lowe, Merlin C.

AU - Barber, Brent J.

AU - Samson, Ricardo A.

PY - 2007/12

Y1 - 2007/12

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AB - Torsades de Pointes (TdP) is a life-threatening ventricular arrhythmia that can be associated with metabolic abnormalities, exposure to arrhythmogenic medications, and congenital long-QT syndrome. This report describes a patient with ALL and multiple complications of therapy who developed TdP. The patient had no evidence of congenital long-QT syndrome, but a constellation of factors appears to have led to QT prolongation, ventricular ectopy, and TdP. Although the patient suffered cardiac arrest, rapid recognition of TdP and prompt defibrillation resulted in an excellent outcome.

KW - Acute lymphocytic leukemia

KW - Cardiac arrest

KW - Torsades de Pointes

KW - Ventricular arrhythmia

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The perfect storm: Torsades de Pointes in a child with leukemia

Abstract

Keywords

ASJC Scopus subject areas

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