Abstract
There is an emerging appreciation that genome-wide association studies (GWAS) have failed to live up to expectations and deliver major advances to date. A "surge" strategy, of pooling resources and increasing number of subjects tested, is underway.Weargue that, while useful, itwill not be enough by itself. Complementary approaches are needed tomine these large datasets.Wedescribe a series of problems, opportunities, and offer a potential comprehensive solution.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 847-849 |
| Number of pages | 3 |
| Journal | American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics |
| Volume | 153 |
| Issue number | 4 |
| DOIs | |
| State | Published - Jun 2010 |
| Externally published | Yes |
Keywords
- Complexity
- Convergent functional genomics (CFG)
- Copy-number variants (CNV)
- Genome-wide association studies (GWAS)
- Psychiatric genetics
ASJC Scopus subject areas
- Genetics(clinical)
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience
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