The origins of SARS-CoV-2: A critical review

Edward C. Holmes; Stephen A. Goldstein; Angela L. Rasmussen; David L. Robertson; Alexander Crits-Christoph; Joel O. Wertheim; Simon J. Anthony; Wendy S. Barclay; Maciej F. Boni; Peter C. Doherty; Jeremy Farrar; Jemma L. Geoghegan; Xiaowei Jiang; Julian L. Leibowitz; Stuart J.D. Neil; Tim Skern; Susan R. Weiss; Michael Worobey; Kristian G. Andersen; Robert F. Garry; Andrew Rambaut

doi:10.1016/j.cell.2021.08.017

The origins of SARS-CoV-2: A critical review

Edward C. Holmes
, Stephen A. Goldstein
, Angela L. Rasmussen
, David L. Robertson
, Alexander Crits-Christoph
, Joel O. Wertheim
, Simon J. Anthony
, Wendy S. Barclay
, Maciej F. Boni
, Peter C. Doherty
, Jeremy Farrar
, Jemma L. Geoghegan
, Xiaowei Jiang
, Julian L. Leibowitz
, Stuart J.D. Neil
, Tim Skern
, Susan R. Weiss
, Michael Worobey
, Kristian G. Andersen
, Robert F. Garry

Andrew Rambaut

Research output: Contribution to journal › Review article › peer-review

385 Scopus citations

Abstract

Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

Original language	English (US)
Pages (from-to)	4848-4856
Number of pages	9
Journal	Cell
Volume	184
Issue number	19
DOIs	https://doi.org/10.1016/j.cell.2021.08.017
State	Published - Sep 16 2021
Externally published	Yes

Keywords

COVID-19
SARS-CoV-2
evolution
origins
zoonosis

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2021.08.017

Cite this

Holmes, E. C., Goldstein, S. A., Rasmussen, A. L., Robertson, D. L., Crits-Christoph, A., Wertheim, J. O., Anthony, S. J., Barclay, W. S., Boni, M. F., Doherty, P. C., Farrar, J., Geoghegan, J. L., Jiang, X., Leibowitz, J. L., Neil, S. J. D., Skern, T., Weiss, S. R., Worobey, M., Andersen, K. G., ... Rambaut, A. (2021). The origins of SARS-CoV-2: A critical review. Cell, 184(19), 4848-4856. https://doi.org/10.1016/j.cell.2021.08.017

Holmes, EC, Goldstein, SA, Rasmussen, AL, Robertson, DL, Crits-Christoph, A, Wertheim, JO, Anthony, SJ, Barclay, WS, Boni, MF, Doherty, PC, Farrar, J, Geoghegan, JL, Jiang, X, Leibowitz, JL, Neil, SJD, Skern, T, Weiss, SR, Worobey, M, Andersen, KG, Garry, RF & Rambaut, A 2021, 'The origins of SARS-CoV-2: A critical review', Cell, vol. 184, no. 19, pp. 4848-4856. https://doi.org/10.1016/j.cell.2021.08.017

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abstract = "Since the first reports of a novel severe acute respiratory syndrome (SARS)-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.",

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AU - Anthony, Simon J.

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AU - Skern, Tim

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KW - evolution

KW - origins

KW - zoonosis

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The origins of SARS-CoV-2: A critical review

Abstract

Keywords

ASJC Scopus subject areas

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