The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood

T. E. Starzl; A. Francavilla; C. G. Halgrimson; F. R. Francavilla; K. A. Porter; T. H. Brown; C. W. Putnam

The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood

T. E. Starzl, A. Francavilla, C. G. Halgrimson, F. R. Francavilla, K. A. Porter, T. H. Brown, C. W. Putnam

Research output: Contribution to journal › Article › peer-review

Abstract

The hepatotrophic factors previously reported to be in splanchnic venous blood are pancreatic hormones and specifically insulin and glucagon. Of these, insulin is anabolic and glucagon is mainly catabolic but not exclusively so, since glucagon also has the anabolic effect of stimulating gluconeogenesis. The insulin glucagon relationship and the interrelationship of these hormones to others, such as epinephrine, in the moment to moment regulation of nutrient and hepatic homeostasis is a central fact of liver physiology that should reconcile a number of previously divergent opinions about portoprival syndromes, mechanisms of hepatic atrophy and hyperplasia, and the control of liver regeneration.

Original language	English (US)
Pages (from-to)	179-199
Number of pages	21
Journal	Unknown Journal
Volume	137
Issue number	2
State	Published - 1973
Externally published	Yes

ASJC Scopus subject areas

Surgery
Obstetrics and Gynecology

Cite this

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abstract = "The hepatotrophic factors previously reported to be in splanchnic venous blood are pancreatic hormones and specifically insulin and glucagon. Of these, insulin is anabolic and glucagon is mainly catabolic but not exclusively so, since glucagon also has the anabolic effect of stimulating gluconeogenesis. The insulin glucagon relationship and the interrelationship of these hormones to others, such as epinephrine, in the moment to moment regulation of nutrient and hepatic homeostasis is a central fact of liver physiology that should reconcile a number of previously divergent opinions about portoprival syndromes, mechanisms of hepatic atrophy and hyperplasia, and the control of liver regeneration.",

author = "Starzl, {T. E.} and A. Francavilla and Halgrimson, {C. G.} and Francavilla, {F. R.} and Porter, {K. A.} and Brown, {T. H.} and Putnam, {C. W.}",

year = "1973",

language = "English (US)",

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T1 - The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood

AU - Starzl, T. E.

AU - Francavilla, A.

AU - Halgrimson, C. G.

AU - Francavilla, F. R.

AU - Porter, K. A.

AU - Brown, T. H.

AU - Putnam, C. W.

PY - 1973

Y1 - 1973

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AB - The hepatotrophic factors previously reported to be in splanchnic venous blood are pancreatic hormones and specifically insulin and glucagon. Of these, insulin is anabolic and glucagon is mainly catabolic but not exclusively so, since glucagon also has the anabolic effect of stimulating gluconeogenesis. The insulin glucagon relationship and the interrelationship of these hormones to others, such as epinephrine, in the moment to moment regulation of nutrient and hepatic homeostasis is a central fact of liver physiology that should reconcile a number of previously divergent opinions about portoprival syndromes, mechanisms of hepatic atrophy and hyperplasia, and the control of liver regeneration.

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JO - Unknown Journal

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ER -

The origin, hormonal nature, and action of hepatotrophic substances in portal venous blood

Abstract

ASJC Scopus subject areas

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