TY - JOUR
T1 - The nutritional prevention of cancer
T2 - 400 Mcg per day selenium treatment
AU - Reid, Mary E.
AU - Duffield-Lillico, Anna J.
AU - Slate, Elizabeth
AU - Natarajan, Nachimuthu
AU - Turnbull, Bruce
AU - Jacobs, Elizabeth
AU - Combs, Gerald F.
AU - Alberts, David S.
AU - Clark, Larry C.
AU - Marshall, James R.
N1 - Funding Information:
Supported in part by National Cancer Institute Grant RO1 CA49764, NIH.
PY - 2008/3
Y1 - 2008/3
N2 - Nonexperimental studies suggest that individuals with higher selenium (Se) status are at decreased risk of cancer. The Nutritional Prevention of Cancer (NPC) study randomized 1,312 high-risk dermatology patients to 200-mcg/day of Se in selenized yeast or a matched placebo; selenium supplementation decreased the risk of lung, colon, prostate, and total cancers but increased the risk of nonmelanoma skin cancer. In this article, we report on a small substudy in Macon, GA, which began in 1989 and randomized 424 patients to 400-mcg/day of Se or to matched placebo. The subjects from both arms had similar baseline Se levels to those treated by 200 mcg, and those treated with 400-mcg attained plasma Se levels much higher than subjects treated with 200 mcg. The 200-mcg/day Se treatment decreased total cancer incidence by a statistically significant 25%; however, 400-mcg/day of Se had no effect on total cancer incidence.
AB - Nonexperimental studies suggest that individuals with higher selenium (Se) status are at decreased risk of cancer. The Nutritional Prevention of Cancer (NPC) study randomized 1,312 high-risk dermatology patients to 200-mcg/day of Se in selenized yeast or a matched placebo; selenium supplementation decreased the risk of lung, colon, prostate, and total cancers but increased the risk of nonmelanoma skin cancer. In this article, we report on a small substudy in Macon, GA, which began in 1989 and randomized 424 patients to 400-mcg/day of Se or to matched placebo. The subjects from both arms had similar baseline Se levels to those treated by 200 mcg, and those treated with 400-mcg attained plasma Se levels much higher than subjects treated with 200 mcg. The 200-mcg/day Se treatment decreased total cancer incidence by a statistically significant 25%; however, 400-mcg/day of Se had no effect on total cancer incidence.
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U2 - 10.1080/01635580701684856
DO - 10.1080/01635580701684856
M3 - Article
C2 - 18444146
AN - SCOPUS:41349107815
SN - 0163-5581
VL - 60
SP - 155
EP - 163
JO - Nutrition and cancer
JF - Nutrition and cancer
IS - 2
ER -