TY - JOUR
T1 - The number of needle passes affects the accuracy of parathyroid hormone assay with intraoperative parathyroid aspiration
AU - Guerrero, Marlon A.
AU - Suh, Insoo
AU - Vriens, Menno R.
AU - Shen, Wen T.
AU - Gosnell, Jessica
AU - Kebebew, Electron
AU - Clark, Orlo H.
AU - Duh, Quan Yang
PY - 2010/12
Y1 - 2010/12
N2 - Introduction Intraoperative aspiration of a nodule and parathyroid hormone (PTH) assay has been shown to accurately confirm parathyroid tissue. However, the reported aspiration technique varies in the literature. We sought to determine if the number of passes affected the accuracy of PTH analysis. Methods A prospective analysis was performed on 25 consecutive patients who underwent a parathyroidectomy for primary hyperparathyroidism. The excised parathyroid gland was aspirated using 1, 3, and 5 passes. The data were analyzed using the Wilcoxon rank, chi-square, and Fisher exact tests to calculate the 2-tailed P value. Results Of the 26 glands aspirated, the mean PTH value varied with the number of passes, 2,073 pg/mL for 1 pass, 2,347 for 3 passes, and 2,695 for 5 passes (P = .02). Accuracy was dependent on the number of passes, with 5 passes (P = .018) having less PTH variation than 1 or 3 passes. Conclusions Aspiration of nodules to determine the PTH level helps confirm the presence of parathyroid tissue. The number of needle passes affects the accuracy of the PTH level, with 5 passes being the optimal number of passes to attain no false-negative results.
AB - Introduction Intraoperative aspiration of a nodule and parathyroid hormone (PTH) assay has been shown to accurately confirm parathyroid tissue. However, the reported aspiration technique varies in the literature. We sought to determine if the number of passes affected the accuracy of PTH analysis. Methods A prospective analysis was performed on 25 consecutive patients who underwent a parathyroidectomy for primary hyperparathyroidism. The excised parathyroid gland was aspirated using 1, 3, and 5 passes. The data were analyzed using the Wilcoxon rank, chi-square, and Fisher exact tests to calculate the 2-tailed P value. Results Of the 26 glands aspirated, the mean PTH value varied with the number of passes, 2,073 pg/mL for 1 pass, 2,347 for 3 passes, and 2,695 for 5 passes (P = .02). Accuracy was dependent on the number of passes, with 5 passes (P = .018) having less PTH variation than 1 or 3 passes. Conclusions Aspiration of nodules to determine the PTH level helps confirm the presence of parathyroid tissue. The number of needle passes affects the accuracy of the PTH level, with 5 passes being the optimal number of passes to attain no false-negative results.
KW - Aspiration technique
KW - Intraoperative
KW - Needle passes
KW - Parathyroid aspiration
KW - Parathyroid hormone assay
KW - Primary hyperparathyroidism
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U2 - 10.1016/j.amjsurg.2010.06.012
DO - 10.1016/j.amjsurg.2010.06.012
M3 - Article
C2 - 21146006
AN - SCOPUS:78650199072
SN - 0002-9610
VL - 200
SP - 701
EP - 706
JO - American journal of surgery
JF - American journal of surgery
IS - 6
ER -