The nucleocapsid protein of zoonotic betacoronaviruses is an attractive target for antiviral drug discovery

Yuekun Lang, Ke Chen, Zhong Li, Hongmin Li

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Betacoronaviruses are in one genera of coronaviruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome-related coronavirus (MERS-CoV), etc. These viruses threaten public health and cause dramatic economic losses. The nucleocapsid (N) protein is a structural protein of betacoronaviruses with multiple functions such as forming viral capsids with viral RNA, interacting with viral membrane protein to form the virus core with RNA, binding to several cellular kinases for signal transductions, etc. In this review, we highlighted the potential of the N protein as a suitable antiviral target from different perspectives, including structure, functions, and antiviral strategies for combatting betacoronaviruses.

Original languageEnglish (US)
Article number118754
JournalLife Sciences
Volume282
DOIs
StatePublished - Oct 1 2021
Externally publishedYes

Keywords

  • Antiviral
  • Betacoronavirus
  • Coronavirus N
  • Nucleocapsid protein
  • Protein-protein interaction

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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