TY - JOUR
T1 - The neural representation of 3-dimensional objects in rodent memory circuits
AU - Burke, Sara N.
AU - Barnes, Carol A.
N1 - Publisher Copyright:
© 2014 Elsevier B.V.
PY - 2015/5/5
Y1 - 2015/5/5
N2 - Three-dimensional objects are common stimuli that rodents and other animals encounter in the natural world that contribute to the associations that are the hallmark of explicit memory. Thus, the use of 3-dimensional objects for investigating the circuits that support associative and episodic memories has a long history. In rodents, the neural representation of these types of stimuli is a polymodal process and lesion data suggest that the perirhinal cortex, an area of the medial temporal lobe that receives afferent input from all sensory modalities, is particularly important for integrating sensory information across modalities to support object recognition. Not surprisingly, recent data from in vivo electrophysiological recordings have shown that principal cells within the perirhinal cortex are activated at locations of an environment that contain 3-dimensional objects. Interestingly, it appears that neural activity patterns related to object stimuli are ubiquitous across memory circuits and have now been observed in many medial temporal lobe structures as well as in the anterior cingulate cortex. This review summarizes behavioral and neurophysiological data that examine the representation of 3-dimensional objects across brain regions that are involved in memory.
AB - Three-dimensional objects are common stimuli that rodents and other animals encounter in the natural world that contribute to the associations that are the hallmark of explicit memory. Thus, the use of 3-dimensional objects for investigating the circuits that support associative and episodic memories has a long history. In rodents, the neural representation of these types of stimuli is a polymodal process and lesion data suggest that the perirhinal cortex, an area of the medial temporal lobe that receives afferent input from all sensory modalities, is particularly important for integrating sensory information across modalities to support object recognition. Not surprisingly, recent data from in vivo electrophysiological recordings have shown that principal cells within the perirhinal cortex are activated at locations of an environment that contain 3-dimensional objects. Interestingly, it appears that neural activity patterns related to object stimuli are ubiquitous across memory circuits and have now been observed in many medial temporal lobe structures as well as in the anterior cingulate cortex. This review summarizes behavioral and neurophysiological data that examine the representation of 3-dimensional objects across brain regions that are involved in memory.
KW - Anterior cingulate cortex
KW - Hippocampus
KW - Lateral entorhinal cortex
KW - Medial prefrontal cortex
KW - Object recognition
KW - Perirhinal cortex central
UR - http://www.scopus.com/inward/record.url?scp=84925368978&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925368978&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2014.09.001
DO - 10.1016/j.bbr.2014.09.001
M3 - Article
C2 - 25205370
AN - SCOPUS:84925368978
SN - 0166-4328
VL - 285
SP - 60
EP - 66
JO - Behavioural Brain Research
JF - Behavioural Brain Research
ER -