The Multiple Layers of the Tumor Environment

Lucie Laplane; Dorothée Duluc; Nicolas Larmonier; Thomas Pradeu; Andreas Bikfalvi

doi:10.1016/j.trecan.2018.10.002

The Multiple Layers of the Tumor Environment

Lucie Laplane
, Dorothée Duluc
, Nicolas Larmonier
, Thomas Pradeu
, Andreas Bikfalvi

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

The notion of tumor microenvironment (TME) has been brought to the forefront of recent scientific literature on cancer. However, there is no consensus on how to define and spatially delineate the TME. We propose that the time is ripe to go beyond an all-encompassing list of the components of the TME, and to construct a multilayered view of cancer. We distinguish six layers of environmental interactions with the tumor and show that they are associated with distinct mechanisms, and ultimately with distinct therapeutic approaches.

Original language	English (US)
Pages (from-to)	802-809
Number of pages	8
Journal	Trends in Cancer
Volume	4
Issue number	12
DOIs	https://doi.org/10.1016/j.trecan.2018.10.002
State	Published - Dec 2018

Keywords

angiogenesis
immune system
niche
tumor microenvironment
tumor organismal environment

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/j.trecan.2018.10.002

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title = "The Multiple Layers of the Tumor Environment",

abstract = "The notion of tumor microenvironment (TME) has been brought to the forefront of recent scientific literature on cancer. However, there is no consensus on how to define and spatially delineate the TME. We propose that the time is ripe to go beyond an all-encompassing list of the components of the TME, and to construct a multilayered view of cancer. We distinguish six layers of environmental interactions with the tumor and show that they are associated with distinct mechanisms, and ultimately with distinct therapeutic approaches.",

keywords = "angiogenesis, immune system, niche, tumor microenvironment, tumor organismal environment",

author = "Lucie Laplane and Doroth{\'e}e Duluc and Nicolas Larmonier and Thomas Pradeu and Andreas Bikfalvi",

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year = "2018",

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doi = "10.1016/j.trecan.2018.10.002",

language = "English (US)",

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TY - JOUR

T1 - The Multiple Layers of the Tumor Environment

AU - Laplane, Lucie

AU - Duluc, Dorothée

AU - Larmonier, Nicolas

AU - Pradeu, Thomas

AU - Bikfalvi, Andreas

PY - 2018/12

Y1 - 2018/12

N2 - The notion of tumor microenvironment (TME) has been brought to the forefront of recent scientific literature on cancer. However, there is no consensus on how to define and spatially delineate the TME. We propose that the time is ripe to go beyond an all-encompassing list of the components of the TME, and to construct a multilayered view of cancer. We distinguish six layers of environmental interactions with the tumor and show that they are associated with distinct mechanisms, and ultimately with distinct therapeutic approaches.

AB - The notion of tumor microenvironment (TME) has been brought to the forefront of recent scientific literature on cancer. However, there is no consensus on how to define and spatially delineate the TME. We propose that the time is ripe to go beyond an all-encompassing list of the components of the TME, and to construct a multilayered view of cancer. We distinguish six layers of environmental interactions with the tumor and show that they are associated with distinct mechanisms, and ultimately with distinct therapeutic approaches.

KW - angiogenesis

KW - immune system

KW - niche

KW - tumor microenvironment

KW - tumor organismal environment

UR - https://www.scopus.com/pages/publications/85055252065

UR - https://www.scopus.com/pages/publications/85055252065#tab=citedBy

U2 - 10.1016/j.trecan.2018.10.002

DO - 10.1016/j.trecan.2018.10.002

M3 - Review article

C2 - 30470302

AN - SCOPUS:85055252065

SN - 2405-8033

VL - 4

SP - 802

EP - 809

JO - Trends in Cancer

JF - Trends in Cancer

IS - 12

ER -

The Multiple Layers of the Tumor Environment

Abstract

Keywords

ASJC Scopus subject areas

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