The motility of mollicutes

Charles W. Wolgemuth; Oleg Igoshin; George Oster

doi:10.1016/S0006-3495(03)74523-8

The motility of mollicutes

Charles W. Wolgemuth, Oleg Igoshin, George Oster

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Recent experiments show that the conformation of filament proteins play a role in the motility and morphology of many different types of bacteria. Conformational changes in the protein subunits may produce forces to drive propulsion and cell division. Here we present a molecular mechanism by which these forces can drive cell motion. Coupling of a biochemical cycle, such as ATP hydrolysis, to the dynamics of elastic filaments enable elastic filaments to propagate deformations that generate propulsive forces. We demonstrate this possibility for two classes of wall-less bacteria called mollicutes: the swimming of helical-shaped Spiroplasma, and the gliding motility of Mycoplasma.

Original language	English (US)
Pages (from-to)	828-842
Number of pages	15
Journal	Biophysical Journal
Volume	85
Issue number	2
DOIs	https://doi.org/10.1016/S0006-3495(03)74523-8
State	Published - Aug 1 2003
Externally published	Yes

ASJC Scopus subject areas

Biophysics

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10.1016/S0006-3495(03)74523-8

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AU - Oster, George

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AB - Recent experiments show that the conformation of filament proteins play a role in the motility and morphology of many different types of bacteria. Conformational changes in the protein subunits may produce forces to drive propulsion and cell division. Here we present a molecular mechanism by which these forces can drive cell motion. Coupling of a biochemical cycle, such as ATP hydrolysis, to the dynamics of elastic filaments enable elastic filaments to propagate deformations that generate propulsive forces. We demonstrate this possibility for two classes of wall-less bacteria called mollicutes: the swimming of helical-shaped Spiroplasma, and the gliding motility of Mycoplasma.

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The motility of mollicutes

Abstract

ASJC Scopus subject areas

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